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Advanced Science, EarlyView.Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao +19 more
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Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes
Advanced Science, EarlyView.PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami +15 more
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["Plasticity" of bone marrow stem cells].
Terapevticheskii arkhiv, 2004 I L Chertkov, N I Drize
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2013
The "mesenchymal stem cells (MSCs)" are cells adherent in the bone marrow, which can be isolated to induce differentiation. In contrast to the "embryonic stem cells" whose goal is to develop a new organism, the "MSC adult stem cells" can participate in tissue growth and repair throughout postnatal life.
Minh Ngoc, Duong +2 more
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The "mesenchymal stem cells (MSCs)" are cells adherent in the bone marrow, which can be isolated to induce differentiation. In contrast to the "embryonic stem cells" whose goal is to develop a new organism, the "MSC adult stem cells" can participate in tissue growth and repair throughout postnatal life.
Minh Ngoc, Duong +2 more
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Regulatory Cells in the Bone Marrow
1976Regulation of the immune system has been attributed primarily to thymus-derived T cells (1,2). Here we present evidence that suppression can be mediated by another cell type, found in the bone marrow, that is neither a T cell nor a macrophage. Others have also shown that bone marrow-derived (B) cell suppression can inhibit both humoral and cell ...
S, Adler, S K, Singhal, E E, Sercarz
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Osteogenesis in transplants of bone marrow cells
Development, 1966ABSTRACT After heterotopic (e.g. subcutaneous) transplantation of bone marrow, haemopoiesis in the graft ceases; reticular tissue develops instead, and later bone is formed (Denis, 1958). The result can be achieved by grafting either free pieces of bone marrow or those placed in diffusion chambers (Petrakova, Tolmacheva & ...
Friedenstein, A J +2 more
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Bone marrow-derived cells and hypertension
Expert Review of Cardiovascular Therapy, 2010Although it is clear that inadequate perfusion underlies most of the organ dysfunction accounting for hypertension-related adverse outcomes, our understanding of the pathophysiologic mechanisms is still evolving. The most important approaches to improving vascular health include reducing injury to the vessel wall and enhancing mechanisms to repair ...
Ki E, Park, Carl J, Pepine
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Bone Reconstruction with Bone Marrow Stromal Cells
2006Bone marrow stromal/stem cells (BMSCs) are multipotent adult stem cells and have become the important cell source for cell therapy and engineered tissue repair. Their osteogenic differentiation potential has been well characterized in many in vitro studies.
Wei, Liu, Lei, Cui, Yilin, Cao
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Cellular Immunology, 1974
Abstract Mouse bone marrow (BM) contains cells capable of responding in vitro to the T cell mitogens, phytohemagglutinin (PHA) and concanavalin A (Con A). These responses are less vigorous than those of spleen cells. The optimal mitogen concentrations for BM cells are different from those for spleen cells; BM cells require twice as much ...
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Abstract Mouse bone marrow (BM) contains cells capable of responding in vitro to the T cell mitogens, phytohemagglutinin (PHA) and concanavalin A (Con A). These responses are less vigorous than those of spleen cells. The optimal mitogen concentrations for BM cells are different from those for spleen cells; BM cells require twice as much ...
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Importance of bone marrow cell dose in bone marrow transplantation
Clinical Transplantation, 1992The importance of the size of the infused marrow cell dose (MCD) was investigated in 274 patients undergoing allogeneic BMT between 1975 and 1990. Among those, 65 had acute myelogenous leukemia (AML), 79 acute lymphoblastic leukemia (ALL), 58 chronic myelogenous leukemia (CML) and 25 severe aplastic anemia (SAA).
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