Results 1 to 10 of about 1,205,734 (289)

The Role of the Bone Marrow Microenvironment in the Response to Infection [PDF]

Frontiers in Immunology, 2020
Hematopoiesis in the bone marrow (BM) is the primary source of immune cells. Hematopoiesis is regulated by a diverse cellular microenvironment that supports stepwise differentiation of multipotent stem cells and progenitors into mature blood cells. Blood
Courtney B. Johnson, Jizhou Zhang, Daniel Lucas, Daniel Lucas   +3 more
doaj   +5 more sources

Bone Marrow Microenvironment and Tumor Progression [PDF]

Cancer Microenvironment, 2008
The bone marrow constitutes an unique microenvironment for cancer cells in three specific aspects. First, the bone marrow actively recruits circulating tumor cells where they find a sanctuary rich in growth factors and cytokines that promote their proliferation and survival.
Olivier Feron, Yves Declerck, Etienne Marbaix   +2 more
exaly   +5 more sources

Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment [PDF]

Frontiers in Cell and Developmental Biology, 2021
Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated.
Lipeng Wang, Hao Zhang, Sicheng Wang, Xiao Chen, Jiacan Su, Jiacan Su   +5 more
doaj   +3 more sources

Immune reprogramming in the bone marrow microenvironment: a new perspective on the bone immune microenvironment of postmenopausal osteoporosis [PDF]

Frontiers in Immunology
Research on postmenopausal osteoporosis (PMOP), a common bone metabolic disease, has traditionally focused on bone loss and imbalance in bone remodeling.
Dingpeng Li, Dingpeng Li, Xianli Zheng, Xianli Zheng, Deming Lin, Yuan Cheng, Zhong Wang, Yangyang Chen, Xingwen Xie, Xingwen Xie   +9 more
doaj   +2 more sources

Mast cells in the bone marrow microenvironment. [PDF]

Front Immunol
The bone marrow microenvironment provides the necessary signals for the development from hematopoietic stem cells into mast cell precursors. Once released in the bloodstream, mast cells quickly migrate to peripheral tissues where they complete their differentiation.
Ribatti D.
europepmc   +4 more sources

CD38 and bone marrow microenvironment

Frontiers in Bioscience - Landmark, 2014
This review summarizes the events ruled by CD38 shaping the bone marrow environment, recapitulating old and new aspects derived from the body of knowledge on the molecule. The disease models considered were myeloma and chronic lymphocytic leukemia (CLL).
Riccardo Ferracini, Alberto Horenstein, Fabio Malavasi   +2 more
exaly   +7 more sources

The bone marrow microenvironment – Home of the leukemic blasts [PDF]

Blood Reviews, 2017
Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow (BM). Ex-vivo AML exhibits a high level of spontaneous apoptosis.
Manar Shafat, Stuart Rushworth, Kristian Bowles   +2 more
exaly   +4 more sources

Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution [PDF]

MedComm
Obesity and aging are major risk factors for diseases such as Type 2 diabetes mellitus, dementia, and osteoporosis. High‐fat diet (HFD) consumption is one of the most important factors contributing to obesity.
Yidan Pang, Siyuan Zhu, Peng Ding, Senyao Zhang, Yi Zhang, Fang Ye, Changqing Zhang, Junjie Gao, Jimin Yin   +8 more
doaj   +2 more sources

Bone Marrow Microenvironment-On-Chip for Culture of Functional Hematopoietic Stem Cells

Frontiers in Bioengineering and Biotechnology, 2022
Hematopoiesis takes place in the bone marrow and is supported by a complex cellular and molecular network in the bone marrow microenvironment. Commonly used models of the human bone marrow microenvironment include murine models and two-dimensional and ...
Azmeer Sharipol, Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Celia A. Soto, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch, Benjamin J. Frisch   +8 more
doaj   +1 more source

Inflammatory bone marrow microenvironment [PDF]

Hematology, 2019
Abstract Self-renewing hematopoietic stem cells and their progeny, lineage-specific downstream progenitors, maintain steady-state hematopoiesis in the bone marrow (BM). Accumulating evidence over the last few years indicates that not only primitive hematopoietic stem and progenitor cells (HSPCs), but also cells defining the ...
Leimkühler, Nils B., Schneider, Rebekka K.   +1 more
openaire   +2 more sources