The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment [PDF]
Frontiers in ImmunologyHematopoietic stem cells (HSCs) undergo self-renewal and differentiation in the bone marrow, which is tightly regulated by cues from the microenvironment.
Xiru Liu +22 more
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The Role of the Bone Marrow Microenvironment in the Response to Infection [PDF]
Frontiers in Immunology, 2020 Hematopoiesis in the bone marrow (BM) is the primary source of immune cells. Hematopoiesis is regulated by a diverse cellular microenvironment that supports stepwise differentiation of multipotent stem cells and progenitors into mature blood cells. Blood
Courtney B. Johnson +3 more
doaj +6 more sources
Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment [PDF]
Frontiers in Cell and Developmental Biology, 2021 Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated.
Lipeng Wang +5 more
doaj +4 more sources
Bone Marrow Microenvironment and Tumor Progression [PDF]
Cancer Microenvironment, 2008 The bone marrow constitutes an unique microenvironment for cancer cells in three specific aspects. First, the bone marrow actively recruits circulating tumor cells where they find a sanctuary rich in growth factors and cytokines that promote their ...
Olivier Feron +2 more
exaly +5 more sources
Bone Marrow Microenvironment-On-Chip for Culture of Functional Hematopoietic Stem Cells
Frontiers in Bioengineering and Biotechnology, 2022 Hematopoiesis takes place in the bone marrow and is supported by a complex cellular and molecular network in the bone marrow microenvironment. Commonly used models of the human bone marrow microenvironment include murine models and two-dimensional and ...
Azmeer Sharipol +8 more
doaj +2 more sources
The Bone Marrow Microenvironment in B-Cell Development and Malignancy
Cancers, 2022 SIMPLE SUMMARY: B cells are an essential component of the immune system and develop in the bone marrow microenvironment. B-cell development is tightly regulated by the stromal cells, fat cells and bone cells in this microenvironment. However, when B-cell
Anastasia M. Hughes +7 more
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Immune reprogramming in the bone marrow microenvironment: a new perspective on the bone immune microenvironment of postmenopausal osteoporosis [PDF]
Frontiers in ImmunologyResearch on postmenopausal osteoporosis (PMOP), a common bone metabolic disease, has traditionally focused on bone loss and imbalance in bone remodeling.
Dingpeng Li +9 more
doaj +2 more sources
Cancers, 2023 Chemoresistance is a significant problem in the effective treatment of bone metastasis. Adipocytes are a major stromal cell type in the bone marrow and may play a crucial role in developing microenvironment-driven chemoresistance.
Jun-Goo Kwak +2 more
exaly +2 more sources
Modeling the Bone Marrow Microenvironment to Better Understand the Pathogenesis, Progression, and Treatment of Hematological Cancers. [PDF]
Cancers (Basel)Despite significant advancements in understanding the pathogenesis and treatment of hematological malignancies, including leukemia and multiple myeloma, the majority of patients continue to experience poor long-term outcomes.
Skelding KA, Barry DL, Lincz LF.
europepmc +2 more sources
Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution [PDF]
MedCommObesity and aging are major risk factors for diseases such as Type 2 diabetes mellitus, dementia, and osteoporosis. High‐fat diet (HFD) consumption is one of the most important factors contributing to obesity.
Yidan Pang +8 more
doaj +2 more sources