Human hematopoietic microenvironments.
PLoS ONE, 2021 Dormancy of hematopoietic stem cells and formation of progenitors are directed by signals that come from the bone marrow microenvironment. Considerable knowledge has been gained on the murine hematopoietic stem cell microenvironment, while less so on the
Helene Bjoerg Kristensen +7 more
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Experimental Hematology & Oncology, 2022 Background The bone marrow is the place of hematopoiesis with a microenvironment that supports lifelong maintenance of stem cells and high proliferation.
Lorenz Nierves +7 more
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The role of bone marrow adipocytes in bone metastasis
Journal of Bone Oncology, 2016 Adipocytes are a significant component of the bone marrow microenvironment. Although bone marrow adipocytes were first identified more than 100 years ago, it is only in recent years that an understanding of their complex physiological role is emerging ...
Emma V. Morris, Claire M. Edwards
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Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]
, 2005 Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Moser, C. +4 more
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Cancers, 2020 The power of immunotherapy in the battle of Multiple Myeloma (MM) started with allogeneic stem cell transplantation, and was rediscovered with immunomodulatory drugs and extended with the outstanding results achieved with targeted antibodies. Today, next
Lisa C. Holthof, T. Mutis
semanticscholar +1 more source
Bone Marrow Senescence and the Microenvironment of Hematological Malignancies [PDF]
Frontiers in Oncology, 2020 Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been associated with a number of age-related pathologies including malignancies.
Charlotte Hellmich +5 more
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Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]
, 2001 Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Thalmeier, Karin +5 more
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Acute Myeloid Leukaemia in Its Niche: the Bone Marrow Microenvironment in Acute Myeloid Leukaemia
Current Oncology Reports, 2020 Purpose of Review Acute myeloid leukaemia (AML) is a heterogeneous malignancy for which treatment options remain suboptimal. It is clear that a greater understanding of the biology of the AML niche will enable new therapeutic strategies to be developed ...
Eleni E Ladikou +5 more
semanticscholar +1 more source
Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia
Clinical Epigenetics, 2023 Background Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow.
Sam Humphries +6 more
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Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering [PDF]
, 2010 Mesenchymal stem/stromal cells (MSC) are typically used to generate bone tissue by a process resembling intramembranous ossification, i.e., by direct osteoblastic differentiation.
Schaeren, Stefan +9 more
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