Results 51 to 60 of about 1,205,734 (289)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Game of Bones: How Myeloma Manipulates Its Microenvironment
Frontiers in Oncology, 2021 Multiple myeloma is a clonal disease of long-lived plasma cells and is the second most common hematological cancer behind Non-Hodgkin’s Lymphoma. Malignant transformation of plasma cells imparts the ability to proliferate, causing harmful lesions in ...
Tyler Moser-Katz +4 more
doaj +1 more source
The bone marrow microenvironment—driver of leukemia evolution? [PDF]
Stem Cell Investigation, 2017 The hematopoietic microenvironment while crucial for maintaining healthy self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) may also be a source for deleterious signals that may cause damage to HSPCs leading to disease (1,2).
Mayra, Garcia, Ching-Cheng, Chen
openaire +2 more sources
Characterization of tenascin-W, an emerging player in the metastatic bone marrow niche [PDF]
, 2015 Tumors are heterogeneous organ-like tissues including not only tumor cells themselves but also auxiliary cells such as, endothelial cells, fibroblasts, inflammatory cells, and bone marrow derived stem or stromal cells (BMSCs), which collectively create ...
Chiovaro, Francesca
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies
Haematologica, 2016 Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis. Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of ...
Abdallah Abou Zahr +7 more
doaj +1 more source
Experimental and Molecular Medicine, 2021 Senile osteoporosis can cause bone fragility and increased fracture risks and has been one of the most prevalent and severe diseases affecting the elderly population.
Daqian Wan +3 more
doaj +1 more source
The Bone Marrow Microenvironment in Health and Myeloid Malignancy [PDF]
Cold Spring Harbor Perspectives in Medicine, 2017 Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the bone marrow (BM) microenvironment or niche. These interactions provide instructive cues that influence the production and lineage determination of different types of blood cells and maintenance of HSC quiescence.
Marta, Galán-Díez +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths
Cell Reports, 2019 Summary: The bone marrow microenvironment is composed of heterogeneous cell populations of non-hematopoietic cells with complex phenotypes and undefined trajectories of maturation.
Samuel L. Wolock +10 more
doaj +1 more source