Results 51 to 60 of about 620,055 (330)
Frontiers in Oncology, 2022 Virtually all patients with multiple myeloma become unresponsive to treatment with proteasome inhibitors over time. Relapsed/refractory multiple myeloma is accompanied by the clonal evolution of myeloma cells with heterogeneous genomic aberrations ...
Jonas Schwestermann +3 more
doaj +1 more source
Neural regulation of bone, marrow, and the microenvironment
Frontiers in Bioscience, 2011 Bone marrow niches are specialized microenvironments comprising a heterogeneous population of cells that support and regulate hematopoietic stem and progenitor cells. Considerable advances made in the field of hematopoiesis reveal a cross talk between cells, cytokines and neurotransmitters of the hematopoietic, immune and skeletal systems.
Jonathan, Canaani +2 more
openaire +2 more sources
Characterization of tenascin-W, an emerging player in the metastatic bone marrow niche [PDF]
, 2015 Tumors are heterogeneous organ-like tissues including not only tumor cells themselves but also auxiliary cells such as, endothelial cells, fibroblasts, inflammatory cells, and bone marrow derived stem or stromal cells (BMSCs), which collectively create ...
Chiovaro, Francesca
core +1 more source
Haematologica, 2020 Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors in progenitor cell adhesion in bone marrow.
J. Gutjahr +24 more
semanticscholar +1 more source
Medičnì Perspektivi, 2018 Bone marrow fibrosis is a key patological feature and major diagnostic criterion of mielofibrosis. Although bone marrow fibrosis is manifested in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis ...
A. S. Timchenko, V. N. Zalessky
doaj +1 more source
The last tenascin : insights on tenascin-W functions and regulation [PDF]
, 2012 Over the last decade, it became clear that the tumor stroma plays an active role in the process of tumor progression, by interacting with the transformed cells and providing a permissive microenvironment for malignant growth.
Martina, Enrico
core +1 more source
Aging Cell, 2018 The alteration of age‐related molecules in the bone marrow microenvironment is one of the driving forces in osteoporosis. These molecules inhibit bone formation and promote bone resorption by regulating osteoblastic and osteoclastic activity ...
Rongyao Xu +9 more
semanticscholar +1 more source
Bone Marrow Immune Microenvironment in Myelodysplastic Syndromes
Cancers, 2022 The BM, the major hematopoietic organ in humans, consists of a pleiomorphic environment of cellular, extracellular, and bioactive compounds with continuous and complex interactions between them, leading to the formation of mature blood cells found in the peripheral circulation.
Olga Kouroukli +4 more
openaire +3 more sources
Frontiers in Biomaterials Science, 2023 Bone metastasis is highly prevalent in breast cancer patients with metastatic disease. These metastatic cells may eventually form osteolytic lesions and affect the integrity of the bone, causing pathological fractures and impairing patient quality of ...
Logan A. Northcutt +8 more
doaj +1 more source
Immune infiltration-related genes regulate the progression of AML by invading the bone marrow microenvironment [PDF]
Frontiers in ImmunologyShuangmei Yu +2 more
exaly +2 more sources