Results 41 to 50 of about 1,205,734 (289)

Bone marrow fibrosis – the basis of mielofibrosis: pathogenesis, prognostication and antifibrogenic targeted strategies.

Medičnì Perspektivi, 2018
Bone marrow fibrosis is a key patological feature and major diagnostic criterion of mielofibrosis. Although bone marrow fibrosis is manifested in a variety of malignant  and non-malignant disease states, the deposition of reticulin and collagen fibrosis ...
A. S. Timchenko, V. N. Zalessky
doaj   +1 more source

The bone marrow microenvironment at single-cell resolution [PDF]

Nature, 2019
The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to stress are incompletely understood. Here we map the transcriptional landscape of mouse bone marrow vascular, perivascular and osteoblast cell populations at single-cell resolution, both at homeostasis and under conditions of stress-
Tikhonova, Anastasia N., Dolgalev, Igor, Hu, Hai, Sivaraj, Kishor K., Hoxha, Edlira, Cuesta-Domínguez, Álvaro, Pinho, Sandra, Akhmetzyanova, Ilseyar, Gao, Jie, Witkowski, Matthew, Guillamot, Maria, Gutkin, Michael C., Zhang, Yutong, Marier, Christian, Diefenbach, Catherine, Kousteni, Stavroula, Heguy, Adriana, Zhong, Hua, Fooksman, David R., Butler, Jason M., Economides, Aris, Frenette, Paul S., Adams, Ralf H., Satija, Rahul, Tsirigos, Aristotelis, Aifantis, Iannis   +25 more
openaire   +2 more sources

The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment

Frontiers in Immunology
Hematopoietic stem cells (HSCs) undergo self-renewal and differentiation in the bone marrow, which is tightly regulated by cues from the microenvironment.
Xiru Liu, Xiru Liu, Xiru Liu, Hao Zhang, Hao Zhang, Hao Zhang, Guolin Shi, Guolin Shi, Guolin Shi, Xinmin Zheng, Xinmin Zheng, Xinmin Zheng, Jing Chang, Jing Chang, Jing Chang, Jing Chang, Quande Lin, Zhenhao Tian, Zhenhao Tian, Zhenhao Tian, Hui Yang, Hui Yang, Hui Yang   +22 more
doaj   +1 more source

Targeting the Microenvironment in MDS: The Final Frontier

Frontiers in Pharmacology, 2020
Myelodysplastic syndromes (MDS) are a heterogeneous group of malignant disorders of hematopoietic stem and progenitor cells (HSPC), mainly characterized by ineffective hematopoiesis leading to peripheral cytopenias and progressive bone marrow failure ...
Patric Teodorescu, Patric Teodorescu, Sergiu Pasca, Delia Dima, Ciprian Tomuleasa, Gabriel Ghiaur   +5 more
doaj   +1 more source

Development of an alginate-Matrigel hydrogel system to evaluate cancer cell behavior in the stiffness range of the bone marrow

Frontiers in Biomaterials Science, 2023
Bone metastasis is highly prevalent in breast cancer patients with metastatic disease. These metastatic cells may eventually form osteolytic lesions and affect the integrity of the bone, causing pathological fractures and impairing patient quality of ...
Logan A. Northcutt, Alyssa M. Questell, Julie Rhoades, Julie Rhoades, Julie Rhoades, Marjan Rafat, Marjan Rafat, Marjan Rafat, Marjan Rafat   +8 more
doaj   +1 more source

Prospective isolation of human bone marrow stromal cell subsets: a comparative study between Stro-1-, CD146- and CD105-enriched populations

, 2014
Stro-1 has proved an efficacious marker for enrichment of skeletal stem and progenitor cells although isolated populations remain heterogeneous, exhibiting variable colony-forming efficiency and osteogenic differentiation potential. The emerging findings
Greenhough, Joanna, Oreffo, Richard, David Gothard, Joanna Greenhough, Ralph, Esther, Gothard, David, Esther Ralph, Richard OC Oreffo   +7 more
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Bone Marrow Immune Microenvironment in Myelodysplastic Syndromes

Cancers, 2022
The BM, the major hematopoietic organ in humans, consists of a pleiomorphic environment of cellular, extracellular, and bioactive compounds with continuous and complex interactions between them, leading to the formation of mature blood cells found in the peripheral circulation.
Olga Kouroukli, Argiris Symeonidis, Periklis Foukas, Myrto-Kalliopi Maragkou, Eleni P. Kourea   +4 more
openaire   +3 more sources

Transplant anxieties : discourses about bone marrow [PDF]

, 2008
Includes bibliographical references (leaves 89-94).This minor dissertation examines the various discourses in the Bone Marrow Transplant (BMT) network in South Africa.
Avera, Emily
core   +1 more source

Generation of osteoinductive grafts by three-dimensional perfusion culture of human bone marrow cells into porous ceramic scaffolds [PDF]

, 2005
The main aims of this thesis were (i) to identify and develop a system that could be reproducibly used to streamline manufacture of osteoinductive grafts based on human bone marrow stromal cells (BMSC) in the context of regenerative medicine, (ii) to ...
Braccini, Alessandra
core   +1 more source

Bone marrow mesenchymal stem cell niches and regenerative medicine [PDF]

, 2010
Mesenchymal progenitors are a powerful tool in regenerative medicine, but suffer from a rapid loss of differentiation potential during in vitro expansion.
Di Maggio, Nunzia
core   +1 more source