Results 41 to 50 of about 620,055 (330)

Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis

Frontiers in Endocrinology, 2018
The high incidences of bone metastasis in patients with breast cancer, prostate cancer and lung cancer still remains a puzzling issue. The “seeds and soil” hypothesis suggested that bone marrow (soil) may provide a favorable “niche” for tumor cells (seed)
Guojing Luo, Yuedong He, Xijie Yu
doaj   +1 more source

Emilin-2 is a component of bone marrow extracellular matrix regulating mesenchymal stem cell differentiation and hematopoietic progenitors

Stem Cell Research & Therapy, 2022
Background Dissection of mechanisms involved in the regulation of bone marrow microenvironment through cell–cell and cell–matrix contacts is essential for the detailed understanding of processes underlying bone marrow activities both under physiological ...
Francesco Da Ros, Luca Persano, Dario Bizzotto, Mariagrazia Michieli, Paola Braghetta, Mario Mazzucato, Paolo Bonaldo   +6 more
doaj   +1 more source

Focus on Osteosclerotic Progression in Primary Myelofibrosis

Biomolecules, 2021
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by hematopoietic stem-cell-derived clonal proliferation, leading to bone marrow (BM) fibrosis.
Mariarita Spampinato, Cesarina Giallongo, Alessandra Romano, Lucia Longhitano, Enrico La Spina, Roberto Avola, Grazia Scandura, Ilaria Dulcamare, Vincenzo Bramanti, Michelino Di Rosa, Nunzio Vicario, Rosalba Parenti, Giovanni Li Volti, Daniele Tibullo, Giuseppe A. Palumbo   +14 more
doaj   +1 more source

Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a 5-y survival of 29%. Immunotherapy is based on the premise that tumors suppress the immune system.
A. Lamble, Y. Kosaka, Ted Laderas, Allie Maffit, A. Kaempf, L. Brady, Weiwei Wang, Nicola Long, Jennifer N Saultz, M. Mori, D. Soong, Clare V Lefave, F. Huang, Homer C. Adams, M. Loriaux, C. Tognon, Pierrette Lo, J. Tyner, G. Fan, S. McWeeney, B. Druker, E. Lind   +21 more
semanticscholar   +1 more source

CD38 and bone marrow microenvironment

Frontiers in Bioscience, 2014
This review summarizes the events ruled by CD38 shaping the bone marrow environment, recapitulating old and new aspects derived from the body of knowledge on the molecule. The disease models considered were myeloma and chronic lymphocytic leukemia (CLL).
Chillemi A, Zaccarello G, Quarona V, Martella E, Ferracini R, Pistoia V, Horenstein AL, Malavasi F., LAZZARETTI, Mirca, GIULIANI, Nicola   +9 more
openaire   +4 more sources

Regulatory interactions in the bone marrow microenvironment [PDF]

IBMS BoneKEy, 2011
Hematopoietic stem cells (HSCs) are the immature, pluripotent cells from which all myeloid and lymphoid cell types originate. As stem cells, HSCs are capable of two very different fate choices: self-renewal, ensuring they will persist throughout the lifetime of an organism, and differentiation to mature progeny. Therapeutic applications of HSCs include
Julianne N, Smith, Laura M, Calvi
openaire   +2 more sources

Isolation and characterization of mesenchymal stem cells from cultured human pancreatic islets of langerhans [PDF]

, 2006
Replacement of insulin producing β-cells that reside within pancreatic islets represents an almost ideal treatment for patients with diabetes mellitus type 1.
Eberhardt, Michael
core   +1 more source

Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors

Stem Cells International, 2020
Although major advances have been achieved in the treatment of chronic myeloid leukemia (CML) by using tyrosine kinase inhibitors, patients relapse after withdrawal and need long-term medication.
Xiaoyan Zhang, Yazhi Yang, Yang Yang, Huijun Chen, Huaijun Tu, Jian Li   +5 more
semanticscholar   +1 more source

Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment

Biomolecules, 2020
Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment.
Jennifer Zarrer, Marie-Therese Haider, Daniel J. Smit, Hanna Taipaleenmäki   +3 more
doaj   +1 more source

Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma

Frontiers in Endocrinology, 2019
The immune system is strongly linked to the maintenance of healthy bone. Inflammatory cytokines, specifically, are crucial to skeletal homeostasis and any dysregulation can result in detrimental health complications.
Danielle Harmer, C. Falank, M. Reagan
semanticscholar   +1 more source