Results 61 to 70 of about 620,055 (330)

Biology of the bone marrow microenvironment and myelodysplastic syndromes [PDF]

Molecular Genetics and Metabolism, 2015
Myelodysplastic syndromes (MDS) are characterized by cytopenias resulting from ineffective hematopoiesis with a predisposition to transform to acute myeloid leukemia (AML). Recent evidence suggests that the hematopoietic stem cell microenvironment contributes to the pathogenesis of MDS. Inflammation and hypoxia within the bone marrow are key regulators
Erinn B, Rankin, Anupama, Narla, Joseph K, Park, Shuo, Lin, Kathleen M, Sakamoto   +4 more
openaire   +2 more sources

Targeting the Microenvironment in MDS: The Final Frontier

Frontiers in Pharmacology, 2020
Myelodysplastic syndromes (MDS) are a heterogeneous group of malignant disorders of hematopoietic stem and progenitor cells (HSPC), mainly characterized by ineffective hematopoiesis leading to peripheral cytopenias and progressive bone marrow failure ...
Patric Teodorescu, Patric Teodorescu, Sergiu Pasca, Delia Dima, Ciprian Tomuleasa, Gabriel Ghiaur   +5 more
doaj   +1 more source

Prospective isolation of human bone marrow stromal cell subsets: a comparative study between Stro-1-, CD146- and CD105-enriched populations

, 2014
Stro-1 has proved an efficacious marker for enrichment of skeletal stem and progenitor cells although isolated populations remain heterogeneous, exhibiting variable colony-forming efficiency and osteogenic differentiation potential. The emerging findings
Greenhough, Joanna, Oreffo, Richard, David Gothard, Joanna Greenhough, Ralph, Esther, Gothard, David, Esther Ralph, Richard OC Oreffo   +7 more
core   +1 more source

Engineered three-dimensional microenvironments as functional in vitro models of stromal tissues [PDF]

, 2014
Currently, the majority of current cultures is still carried out with long-established techniques like the exploitation of 2D supports, the use of tissue-derived immortalized cell lines, and the administration of un-physiological doses of soluble factors
Piccinini, Elia
core   +1 more source

Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia

Cancer Cell, 2017
Summary The biological and clinical behaviors of hematological malignancies can be influenced by the active crosstalk with an altered bone marrow (BM) microenvironment.
D. Passaro, A. di Tullio, A. Abarrategi, K. Rouault-Pierre, K. Foster, L. Ariza-McNaughton, B. Montaner, P. Chakravarty, Leena Bhaw, Giovanni Diana, F. Lassailly, J. Gribben, D. Bonnet   +12 more
semanticscholar   +1 more source

A specialized bone marrow microenvironment for fetal haematopoiesis

Nature Communications, 2022
Abstract In adult mammalian bone marrow (BM), vascular endothelial cells and perivascular reticular cells control the function of haematopoietic stem and progenitor cells (HSPCs). During fetal development, the mechanisms regulating the de novo haematopoietic cell colonization of BM remain largely unknown. Here, we
Yang Liu, Qi Chen, Hyun-Woo Jeong, Bong Ihn Koh, Emma C. Watson, Cong Xu, Martin Stehling, Bin Zhou, Ralf H. Adams   +8 more
openaire   +3 more sources

Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.

Blood, 2019
Acute myeloid leukemia (AML) is an age-related disease that is highly dependent on the bone marrow (BM) microenvironment. With increasing age, tissues accumulate senescent cells, characterized by an irreversible arrest of cell proliferation and the ...
A. Abdul-Aziz, Yu Sun, C. Hellmich, Christopher R. Marlein, J. Mistry, E. Forde, Rachel E. Piddock, Manar S Shafat, Adam Morfakis, Tarang K. Mehta, F. Di Palma, I. Macaulay, Christopher J Ingham, A. Haestier, Angela Collins, J. Campisi, K. Bowles, S. Rushworth   +17 more
semanticscholar   +1 more source

The Bone Marrow Microenvironment in Health and Myeloid Malignancy. [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the bone marrow (BM) microenvironment or niche. These interactions provide instructive cues that influence the production and lineage determination of different types of blood cells and maintenance of HSC quiescence.
M. Galán-Díez, Alvaro Cuesta-Dominguez, S. Kousteni   +2 more
semanticscholar   +3 more sources

Game of Bones: How Myeloma Manipulates Its Microenvironment

Frontiers in Oncology, 2021
Multiple myeloma is a clonal disease of long-lived plasma cells and is the second most common hematological cancer behind Non-Hodgkin’s Lymphoma. Malignant transformation of plasma cells imparts the ability to proliferate, causing harmful lesions in ...
Tyler Moser-Katz, Nisha S. Joseph, Madhav V. Dhodapkar, Kelvin P. Lee, Lawrence H. Boise   +4 more
doaj   +1 more source

Engineering the tumor microenvironment of colorectal cancer [PDF]

, 2014
The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
core   +1 more source