Results 81 to 90 of about 620,055 (330)

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]

, 2004
Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Seliger, Christian, Huss, Ralf, Kinston, Sarah, Gottgens, Berthold, Heil, Matthias, Sabine Moosmann, Matthias Heil, Christian Seliger, Sabine Sagebiel, Berthold Gottgens, Tibor Ziegelhoeffer, Moosmann, Sabine, Ralf Huss, Sarah Kinston, Ziegelhoeffer, Tibor, Sagebiel, Sabine   +15 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy

Scientific Reports, 2022
CD19 CAR T-cell immunotherapy is a breakthrough treatment for B cell malignancies, but relapse and lack of response remain a challenge. The bone marrow microenvironment is a key factor in therapy resistance, however, little research has been reported ...
Lipei Shao, Avinash Iyer, Yingdong Zhao, Rob Somerville, Sandhya Panch, Alejandra Pelayo, David F. Stroncek, Ping Jin   +7 more
doaj   +1 more source

CD137 Regulates Bone Loss via the p53 Wnt/β-Catenin Signaling Pathways in Aged Mice

Frontiers in Endocrinology, 2022
Senile osteoporosis is a chronic skeletal disease, leading to increased bone brittleness and risk of fragile fractures. With the acceleration of population aging, osteoporosis has gradually become one of the most serious and prevalent problems worldwide.
Jiyu Han, Jiyu Han, Yanhong Wang, Yanhong Wang, Haichao Zhou, Haichao Zhou, Yingqi Zhang, Daqian Wan, Daqian Wan   +8 more
doaj   +1 more source

Characterization of early mouse mesenchymal stem/progenitor cells for generating cartilage and study their role in endochondral ossification [PDF]

, 2016
Mesenchymal stem/ stromal cells (MSCs) isolated from mice have allowed to address some of the major issues that could not be investigated by using human MSCs.
Jaiswal, Sumit
core   +1 more source

Bone marrow microenvironment: The guardian of leukemia stem cells

World Journal of Stem Cells, 2019
Bone marrow microenvironment (BMM) is the main sanctuary of leukemic stem cells (LSCs) and protects these cells against conventional therapies. However, it may open up an opportunity to target LSCs by breaking the close connection between LSCs and the ...
M. Houshmand, Teresa Mortera Blanco, P. Circosta, Narjes Yazdi, A. Kazemi, G. Saglio, M. N. Zarif   +6 more
semanticscholar   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53

Stem Cells International, 2021
Survival of mesenchymal stem cells in the bone marrow is essential for bone marrow microenvironment homeostasis, but the molecular mechanisms remain poorly understood.
Qing Tian, Chen Cao, Weijian Qiu, Han Wu, Lijun Zhou, Zhipeng Dai, Zhenwei Li, Songfeng Chen   +7 more
doaj   +1 more source

Notochordal inclusions in the vertebral bone marrow

, 2008
Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI-detectable lesion without osteolysis, and their detection may cause concern or overtreatment.
Ernesto Ippolito, IPPOLITO, ERNESTO, BIANCO, Paolo, MANCINI F, RIMINUCCI, MARA, CORSI, ALESSANDRO, Bianco, P, Mancini, F, Fernando De Maio, De Maio, F, Riminucci, M, Bianco, P., Federico Mancini, DE MAIO, FERNANDO, MANCINI, FEDERICO, Alessandro Corsi, IPPOLITO E, Ippolito, E, Corsi, A, DE MAIO F, Mara Riminucci, Paolo Bianco   +21 more
core   +1 more source

Epigenetic drug combination overcomes bone marrow microenvironment-induced chemprotection in pediatric acute lymphoblastic leukemia via modulation of CD81 and BTK

, 2020
Selva, Erica M.Acute Lymphoblastic Leukemia (ALL) is the most commonly diagnosed cancer in pediatric patients in the United States. While recent advances have improved remission rates to upwards of 95%, ALL is still plagued by relapse in nearly 20% of ...
Quagliano, Anthony Joseph
core   +1 more source