Results 81 to 90 of about 1,205,734 (289)

Erythropoiesis, anemia and the bone marrow microenvironment

International Journal of Hematology, 2011
The in vivo regulation of erythropoiesis involves the integration of a range of intrinsic and cell extrinsic cues. The macrophage contained within the erythroblastic island is central to the normal differentiation and support of erythroid development.
openaire   +4 more sources

Multiple Myeloma : an update on disease biology and therapy [PDF]

, 2004
Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and ...
Dingli, David, Cook, Rachel J.
core  

Intracarotid administration of human bone marrow mononuclear cells in rat photothrombotic ischemia [PDF]

, 2010
Background: Increasing evidence suggests that cell therapy improves functional recovery in experimental models of stroke and myocardial infarction.
Wolf-Rüdiger Schäbitz, Kuhnert, Katharina, Kai Diederich, Jens Minnerup, Minnerup, Jens, Matthias Schilling, Schilling, Matthias, Seeger, Florian Hartmut, Schäbitz, Wolf-Rüdiger, Stefanie Dimmeler, Dimmeler, Stefanie, Florian H Seeger, Diederich, Kai, Katharina Kuhnert   +13 more
core   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

The role of bone marrow derived cells in cardiac repair [PDF]

, 2012
PhDCurrent pharmacological therapies fail to address the final end-point of cardiac ischaemia — the death and dysfunction of cardiomyocytes. Advances in stem cell biology have provided hope, for the first time, of addressing this underlying pathology.
Lovell, Matthew J.
core   +4 more sources

Neonatal bone marrow interstitial fluid supports expansion and osteogenic ability of human bone marrow mesenchymal stromal cells

Bone Research
The bone marrow microenvironment is critical for the maintenance and functionality of stem/progenitor cells, which are essential for bone development and regeneration.
Junfeng Zhang, Tengjiao Ma, Lan Ke, Huan Zhang, Jiaxin Hu, Shunping Li, Hailong Wang, Anming Meng   +7 more
doaj   +1 more source

The bone marrow derived- stromal cells: commitment and regulation of adipogenesis

Frontiers in Endocrinology, 2016
Bone marrow microenvironment represents an important compartment of bone that regulates bone homeostasis and the balance between bone formation and bone resorption depending on the physiological needs of the organism.
Michaela Tencerova, Michaela Tencerova, Moustapha Kassem, Moustapha Kassem, Moustapha Kassem   +4 more
doaj   +1 more source

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Niche TWIST1 is critical for maintaining normal hematopoiesis and impeding leukemia progression

Haematologica, 2018
The bone marrow microenvironment regulates normal and malignant hematopoiesis, but the underlying molecular mechanisms remain poorly defined. Using a chimeric mice model, we demonstrate that Twist1 deletion in the bone marrow microenvironment results in ...
Xiaoyan Liu, Yanping Ma, Rongrong Li, Dan Guo, Nan Wang, Yangyang Zhao, Jing Yin, Qian Ren, Yongmin Lin, Xiaotong Ma   +9 more
doaj   +1 more source