Results 101 to 110 of about 620,055 (330)

The impact of the bone marrow microenvironment on multiple myeloma (Review).

Oncology Report, 2019
Multiple myeloma (MM) is characterized by the accumulation of monoclonal plasma cells in the bone marrow (BM). The interaction between the BM microenvironment and MM plasma cells can influence cell proliferation, drug resistance and prognosis of the ...
Jianhao Hou, Rongfang Wei, Jinjun Qian, Ronggen Wang, Z. Fan, C. Gu, Ye Yang   +6 more
semanticscholar   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

The bone marrow microenvironment—driver of leukemia evolution? [PDF]

Stem Cell Investigation, 2017
The hematopoietic microenvironment while crucial for maintaining healthy self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) may also be a source for deleterious signals that may cause damage to HSPCs leading to disease (1,2).
Mayra, Garcia, Ching-Cheng, Chen
openaire   +2 more sources

CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment

Tumor Biology, 2017
The major cause of death in osteosarcoma is the invasion and metastasis. Better understanding of the molecular mechanism of osteosarcoma invasion is essential in developing effective tumor-suppressive therapies.
Yan Han, Chunlei Wu, Jing Wang, Na Liu
doaj   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

The bone marrow microenvironment as a mediator of chemoresistance in acute lymphoblastic leukemia

Cancer Drug Resistance, 2019
Acute lymphoblastic leukemia (ALL) is a malignancy of immature lymphoid cells that arises due to clonal expansion of cells that undergo developmental arrest and acquisition of pathogenic mutations.
Lauren K Meyer, M. Hermiston
semanticscholar   +1 more source

Bone Marrow Adipose Tissue

Cells
Bone marrow (BM) acts as a dynamic organ within the bone cavity, responsible for hematopoiesis, skeletal remodeling, and immune system control. Bone marrow adipose tissue (BMAT) was long simply considered a filler of space, but now it is known that it ...
Elena Marinelli Busilacchi, Erika Morsia, Antonella Poloni   +2 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Regulation of Malignant Hematopoiesis by Bone Marrow Microenvironment [PDF]

Frontiers in Oncology, 2018
Hematopoietic stem cells (HSCs) that give rise to all kinds of hematopoietic lineage cells on various demands throughout life are maintained in a specialized microenvironment called "niche" in the bone marrow (BM). Defining niche cells and unveiling its function have been the subject of intense study, and it is becoming increasingly clear how niche ...
openaire   +3 more sources

A hostel for the hostile: the bone marrow niche in hematologic neoplasms

Haematologica, 2015
Our understanding of the biology of the normal hematopoietic stem cell niche has increased steadily due to improved murine models and sophisticated imaging tools. Less well understood, but of growing interest, is the interaction between cells in the bone
Daniela S. Krause, David T. Scadden
doaj   +1 more source