Results 101 to 110 of about 1,205,734 (289)

Oncogenomics to Target Myeloma in the Bone Marrow Microenvironment [PDF]

Clinical Cancer Research, 2011
AbstractMultiple myeloma (MM) is an example of rapid bench-to-bedside translation in new drug development. Bortezomib and lenalidamide target the tumor cell in the bone marrow microenvironment to overcome drug resistance in laboratory and animal models; each is effective to treat relapsed and/or refractory, relapsed, and newly diagnosed MM, and both ...
openaire   +2 more sources

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Notochordal inclusions in the vertebral bone marrow

, 2008
Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI-detectable lesion without osteolysis, and their detection may cause concern or overtreatment.
Ernesto Ippolito, IPPOLITO, ERNESTO, BIANCO, Paolo, MANCINI F, RIMINUCCI, MARA, CORSI, ALESSANDRO, Bianco, P, Mancini, F, Fernando De Maio, De Maio, F, Riminucci, M, Bianco, P., Federico Mancini, DE MAIO, FERNANDO, MANCINI, FEDERICO, Alessandro Corsi, IPPOLITO E, Ippolito, E, Corsi, A, DE MAIO F, Mara Riminucci, Paolo Bianco   +21 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

In vitro and in vivo characterization of murine bone marrow stromal stem cells: self renewal, differentiation, tumorigenic potential [PDF]

, 2009
The use of adult stem cells for applications such as tissue engineering and gene therapy is one of the major challenge approaches of regenerative medicine. In the field of adult stem cells, bone marrow stromal cells (BMSCs) are very promising candidates.
Esposito, Maria Teresa
core   +1 more source

1ST BONE MARROW ADIPOSITY SOCIETY (BMAS) SUMMER SCHOOL

, 2021
The bone marrow in adults consists mostly of fat. There is a direct relationship between bone marrow fat and the occurrence of bone fractures or osteoporosis.
Annegreet Veldhuis, Rita Sarkis, Sarah Little, Michaela Tencerova, Viktorija Avilkina, Biagio Palmisano, Rossella Labella   +6 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Altered bone marrow niche forms central innate immune memory driving cardiac dysfunction

Nature Communications
We previously showed that heart failure induces innate immune memory in hematopoietic stem and progenitor cells, which contributes to recurrence of heart failure and impaired stress responses in multiple organs.
Kohsaku Goto, Yukiteru Nakayama, Junichi Sugita, Tsukasa Oshima, Kunihito Kani, Atsushi Kobayashi, Naoto Setoguchi, Yuxiang Liu, Yiyi Yang, Jiaxin Ku, Ryoko Uchida, Eriko Hasumi, Takashi Nagasawa, Issei Komuro, Norihiko Takeda, Ichiro Manabe, Katsuhito Fujiu   +16 more
doaj   +1 more source