Results 121 to 130 of about 620,055 (330)

Targeted Delivery of c(RGDfk)‐Modified Liposomes to Bone Marrow Through In Vivo Hitchhiking Neutrophils for Multiple Myeloma Therapy

Advanced Science
Multiple myeloma (MM) is a prevalent bone marrow disorder. The challenges in managing MM include selecting chemotherapy regimens that effectively modulate the myeloma microenvironment and delivering them to the bone marrow with high efficacy and minimal ...
Huiwen Liu, Bo Zhang, Hongrui Chen, Honglan Wang, Xifeng Qin, Chunyan Sun, Zhiqing Pang, Yu Hu   +7 more
doaj   +1 more source

Inflammatory pathways and the bone marrow microenvironment in inherited bone marrow failure syndromes. [PDF]

Stem Cells
Abstract Inherited bone marrow failure syndromes (IBMFS) are a diverse group of genetic disorders characterized by insufficient hematopoietic cell production due to blood stem cell dysfunction. The most common syndromes are Fanconi Anemia, Diamond-Blackfan Anemia, and Shwachman-Diamond Syndrome.
Neoman N, Kim HN, Viduya J, Goyal A, Liu YL, Sakamoto KM.   +5 more
europepmc   +3 more sources

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

Frontiers in Immunology, 2016
All hematopoietic and immune cells are continuously generated by hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of stepwise lineage commitment.
Larisa V. Kovtonyuk, K. Fritsch, Xiaomin Feng, M. Manz, Hitoshi Takizawa   +4 more
semanticscholar   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Rat Prostate Tumor Cells Progress in the Bone Microenvironment to a Highly Aggressive Phenotype

Neoplasia: An International Journal for Oncology Research, 2016
Prostate cancer generally metastasizes to bone, and most patients have tumor cells in their bone marrow already at diagnosis. Tumor cells at the metastatic site may therefore progress in parallel with those in the primary tumor.
Sofia Halin Bergström, Stina H Rudolfsson, Anders Bergh   +2 more
doaj   +1 more source

cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis

, 2009
Background Endothelium-derived nitric oxide plays an important role for the bone marrow microenvironment. Since several important effects of nitric oxide are mediated by cGMP-dependent pathways, we investigated the role of the cGMP downstream effector ...
Feil, Robert, Hofmann, Franz, Alexandra Aicher, Michael E. Mendelsohn, Aicher, Alexandra, Michael E Mendelsohn, Mendelsohn, Michael E., Alexandra Aicher, Heeschen, Christopher, Feil, Susanne, Christopher Heeschen, Stefanie Dimmeler, Dimmeler, Stefanie, Franz Hofmann, Susanne Feil, Robert Feil   +15 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Bone Marrow Microenvironment in Multiple Myeloma Progression [PDF]

, 2013
Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment.
Manier, S., Sacco, A., Ghobrial, Irene, Leleu, X., Roccaro, Aldo M.   +4 more
core   +1 more source

Mobilization of Hematopoietic Stem Cells as a Result of Innate Immunity- Mediated Sterile Inflammation in the Bone Marrow Microenvironment—the Involvement of Extracellular Nucleotides and Purinergic Signaling

Leukemia, 2018
Hematopoietic stem/progenitor cells (HSPCs) circulate in peripheral blood (PB) under normal conditions and their number increases in response to stress, inflammation, tissue/organ injury, and may increase up to 100-fold after administration of ...
M. Ratajczak, M. Adamiak, Monika Plonka, A. Abdel-Latif, J. Ratajczak   +4 more
semanticscholar   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source