Results 141 to 150 of about 620,055 (330)

Increased Bone Marrow Adiposity in a Context of Energy Deficit: The Tip of the Iceberg?

, 2016
Elevated bone marrow adiposity is defined as an increase in the proportion of the bone marrow cavity volume occupied by adipocytes. This can be caused by an increase in the size and/or number of adipocytes.
Christophe Chauveau, Ghali Mhenni, Olfa, Olfa Ghali, Nathalie Al Rassy, Hardouin, Pierre, Pierre Hardouin, Chauveau, Christophe, Rassy, N., Rassy, Nathalie   +8 more
core   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

2559 Role of tissue non-specific alkaline phosphatase (TNAP) in promoting the survival of acute myeloid leukemia (AML) cells within the bone marrow microenvironment

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Treatment of acute myeloid leukemia (AML) is challenging, as apoptosis-resistant AML cells often persist within the bone marrow microenvironment despite chemotherapy.
Bradley Bowles, Rosalie M. Sterner, Kimberly N. Kremer, Amel Dudakovic, Jennifer J. Westendorf, Andre J. Van Wijnen, Karen E. Hedin   +6 more
doaj   +1 more source

Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation

, 2013
Background: Osteoinductive bone substitutes are defined by their ability to induce new bone formation even at heterotopic implantation sites. The present study was designed to analyze the potential osteoinductivity of two different bone substitute ...
Künzel, Oliver, Shahram Ghanaati, Ines Willershausen, Ghanaati, Shahram Michael, Samuel E. Udeabor, Robert A. Sader, Oliver Kuenzel, Sader, Robert Alexander, Udeabor, Samuel Ebele, Kirkpatrick, Charles James, C. James Kirkpatrick, Willershausen, Ines Bettina Anne, Mike Barbeck, Barbeck, Mike   +13 more
core   +1 more source

Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase

, 2020
Cancer cells facilitate growth and metastasis by using multiple signals from the cancer-associated microenvironment. However, it remains poorly understood whether prostate cancer (PCa) cells may recruit and utilize bone marrow cells for their growth and ...
Tianyan Wang, Miftakhova, Regina R., Ekström-Holka, Kristina,, Jenny L. Persson, Ødum, Niels,, Miftakhova, Regina R.,, Syed Khaja, Azharuddin Sajid,, Khaja, Azharuddin Sajid Syed,, Grundström, Thomas, Richard Karlsson, Ødum, Nils, Chen, Sa, Julius Semenas, Karlsson, Richard,, Larsson, Per,, Miftakhova, Regina, Semenas, Julius,, Ødum, Niels, Sarwar, Martuza, Semenas, Julius, Khaja, Azharuddin Sajid Syed, Hedblom, Andreas, Chen, Sa,, Kristina Ekström-Holka, Syed Khaja, Azharuddin Sajid, Lund University., Wang, Tianyan, Niels Ødum, Persson, Jenny L., Andreas Hedblom, Athanasios Simoulis, Larsson, Per, Martuza Sarwar, Sarwar, Martuza,, Ekström-Holka, Kristina, Simoulis, Athanasios,, Thomas Grundström, Kumar, Anjani, Azharuddin Sajid Syed Khaja, Persson, Jenny L.,, Regina Miftakhova, Anjani Kumar, Simoulis, Athanasios, Hedblom, Andreas,, Sa Chen, Grundström, Thomas,, Kumar, Anjani,, Per Larsson, Wang, Tianyan,, Miftakhova, Regina,, Karlsson, Richard   +50 more
core   +1 more source

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia

Haematologica, 2017
Fanconi anemia is a complex heterogeneous genetic disorder with a high incidence of bone marrow failure, clonal evolution to acute myeloid leukemia and mesenchymal-derived congenital anomalies.
Yuan Zhou, Yuan Zhou, Yongzheng He, W. Xing, W. Xing, Peng Zhang, Hui Shi, Hui Shi, Shi Chen, Jun Shi, J. Bai, Steven D. Rhodes, Feng-kui Zhang, Jin Yuan, Xianlin Yang, Xiaofan Zhu, Yan Li, H. Hanenberg, H. Hanenberg, Mingjiang Xu, K. Robertson, W. Yuan, G. Nalepa, T. Cheng, D. Clapp, Feng-Chun Yang   +25 more
semanticscholar   +1 more source

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source

Injectable Cell-based Tissue Engineered Bone Formulations

, 2010
PhDCurrent golden standard therapy for bone repair and regeneration involves the use of auto grafts. Nevertheless, there are many drawbacks associated with auto grafts including donor site morbidity, requirement for an invasive surgery, post-operative
Ahmadi, Raheleh
core  

Osteoblast versus Adipocyte: Bone Marrow Microenvironment-Guided Epigenetic Control

, 2018
The commitment and differentiation of bone marrow mesenchymal stem cells (MSCs) is tightly controlled by the local environment ensuring lineage differentiation balance and bone homeostasis.
Jiao Li, Liming Dai, Xiaoling Zhang, Bin Zuo, Li Zhang   +4 more
core   +1 more source

Bone marrow microenvironment as a regulator and therapeutic target for prostate cancer bone metastasis

Calcified Tissue International, 2017
Bone is the most common site of prostate cancer metastasis. Once prostate cancer cells metastasize to bone, the mortality rate of prostate cancer patients increases significantly.
S. Park, E. Keller, Y. Shiozawa
semanticscholar   +1 more source