Results 161 to 170 of about 620,055 (330)
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Cutaneous Mast Cell Maturation Does Not Depend on an Intact Bone Marrow Microenvironment
, 1984 We sought to determine whether the maturation of murine cutaneous mast cells from stem cells depends on an intact bone marrow microenvironment. Normal bone marrow cells (+/+) were infused into 2 groups of mast cell-deficient mice: WBB6F1-W/Wv mice and ...
Charley, Michael R. +4 more
core +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Bone Marrow Microenvironment in Acute Myleoid Leukemia
, 2013 Acute myeloid leukemia (AML) often remains refractory to current chemotherapy and transplantation approaches despite many advances in our understanding of mechanisms in leukemogenesis.
Chandran, Priya
core +2 more sources
Modelling stromal FAK regulation of tumour growth, angiogenesis and progression
, 2012 PhDThe growth of tumours within a whole organism depends on the tumour microenvironment. This involves both resident stromal cells, such as endothelial cells and fibroblasts, and also bone marrow derived stromal cells.
Batista, Silvia
core
Diferenciação in vivo de células-tronco mesenquimais de placenta humana em fenótipo neural e seu potencial terapêutico para o tratamento de acidente vascular cerebral [PDF]
, 2013 Tese (doutorado)- Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2013.As células-tronco (CTs) são células indiferenciadas com habilidade de se autorrenovar, e que em ...
Martini, Maristela Maria
core
Advanced Science, EarlyView.This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia +5 more
wiley +1 more source
Bone as a Preferential Site for Metastasis
JBMR Plus, 2019 Bone marrow provides a unique microenvironment favoring the colonization and outgrowth of metastatic tumor cells. Despite the high incidence of bone metastasis in breast and prostate cancer patients, many of the molecular mechanisms controlling ...
Miranda E Sowder, Rachelle W Johnson
doaj +1 more source
Intravital Multiphoton Microscopy Analysis of Spatial Relationships in Murine Skull Bone Marrow [PDF]
, 2009 The BM is a key organ of hematopoiesis and also has an important role in the immune system. The BM microenvironment is a complex, highly vascularized 3D structure composed of different cell types and extracellular matrix.
Engelke, Katharina
core
Advanced Science, EarlyView.Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen +14 more
wiley +1 more source