Results 181 to 190 of about 1,205,734 (289)

P007 | Pre-clinical efficacy of a novel combined pharmacological approach targeting JAK and ERK in a myelofibrosis mouse model

Haematologica
Introduction: Myelofibrosis (MF) is the most severe form of Philadelphia–negative myeloproliferative neoplasms (MPNs), characterized by high risk of leukemic transformation and reduced survival.
Matteo Bertesi
doaj  

Multimodal imaging evaluation of hypoxic bone marrow microenvironment and type H vascular injury in diabetes. [PDF]

Sci Rep
Lei H, Wang K, Li L, Liu C, Zha Y.
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis? [PDF]

Leukemia
Mian SA, Ngo S, Bonnet D.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment. [PDF]

Blood
Gort-Freitas NA, Moscvin M, Da Vià MC, Lazzaroni F, Nevone A, Sadigh S, Boullt S, Evans B, Chen T, Karagiannis T, Tai A, Rowell S, Raghav S, Chen AF, Laubach JP, Edwards C, Aster JC, Sheng Z, Paulo JA, Chan CN, Nuvolone M, Bolli N, Comenzo RL, Klein AM, Bianchi G.   +24 more
europepmc   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Mesenchymal stromal cells secretory pattern contributes to oncoinflammatory bone marrow microenvironment in polycythemia vera. [PDF]

Hematol Transfus Cell Ther
Cominal JG, Cacemiro MDC, Berbel GM, Rahimy RML, Rocha GV, Zanette DL, Oliveira MC, Figueiredo-Pontes LL, Malmegrim KCR, Castro FA.   +9 more
europepmc   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

BMDB: An integrated database and web platform for single-cell transcriptomic profiling of bone marrow microenvironment. [PDF]

Comput Struct Biotechnol J
Chen J, Yu H, Bian C, Hu Y, Sui K, Zhang X, Wang Z.   +6 more
europepmc   +1 more source