Results 21 to 30 of about 620,055 (330)
Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development
Experimental Hematology & Oncology, 2021 Despite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the ...
Yiyi Yao +4 more
semanticscholar +1 more source
The interplay of leukemia cells and the bone marrow microenvironment. [PDF]
Blood, 2018 Abstract The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussions on the growth of leukemic ...
D. Duarte, E. Hawkins, Cristina Lo Celso
semanticscholar +4 more sources
International Journal of Molecular Sciences, 2022 Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival rates of all cancers. The bone marrow microenvironment is increasingly being recognised as an important mediator of AML chemoresistance and relapse, supporting ...
K. Skelding +3 more
semanticscholar +1 more source
The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
Frontiers in Cell and Developmental Biology, 2021 Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well characterized niches to produce molecular and cellular mechanisms that ...
D. B. Pimenta +5 more
semanticscholar +1 more source
The impacts of exosomes on bone metastatic progression and their potential clinical utility
Bone Reports, 2022 Bone is one of the most common sites of cancer metastasis. Once cancer metastasizes to the bone, the mortality rate of cancer patients dramatically increases. Although the exact mechanisms for this observation remain elusive, recent studies have revealed
Jenna Ollodart +3 more
doaj +1 more source
The role of the bone microenvironment in regulating myeloma residual disease and treatment
Frontiers in Oncology, 2022 Multiple myeloma is an incurable haematological cancer. The increase in targeted therapies has improved the number of myeloma patients achieving a complete response and improved progression-free survival following therapy. However, a low level of disease
Terry G. Dadzie, Alanna C. Green
doaj +1 more source
Journal of Oncology, 2021 In the hematopoietic microenvironment, leukemic cells secrete factors that imbalanced chemokine and cytokine production. However, the network of soluble immunological molecules in the bone marrow microenvironment of acute lymphoblastic leukemia (ALL ...
F. Magalhães-Gama +13 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells.
Laura Mosteo +9 more
doaj +1 more source
Obesity-Induced Changes in Bone Marrow Homeostasis
Frontiers in Endocrinology, 2020 Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic ...
Andrea Benova, Michaela Tencerova
doaj +1 more source
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis. [PDF]
PLoS ONE, 2009 The bone-bone marrow interface is an area of the bone marrow microenvironment in which both bone remodeling cells, osteoblasts and osteoclasts, and hematopoietic cells are anatomically juxtaposed.
April S Chan +8 more
doaj +1 more source