Results 11 to 20 of about 1,205,734 (289)
The impacts of exosomes on bone metastatic progression and their potential clinical utility
Bone Reports, 2022 Bone is one of the most common sites of cancer metastasis. Once cancer metastasizes to the bone, the mortality rate of cancer patients dramatically increases. Although the exact mechanisms for this observation remain elusive, recent studies have revealed
Jenna Ollodart +3 more
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The role of the bone microenvironment in regulating myeloma residual disease and treatment
Frontiers in Oncology, 2022 Multiple myeloma is an incurable haematological cancer. The increase in targeted therapies has improved the number of myeloma patients achieving a complete response and improved progression-free survival following therapy. However, a low level of disease
Terry G. Dadzie, Alanna C. Green
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Human hematopoietic microenvironments.
PLoS ONE, 2021 Dormancy of hematopoietic stem cells and formation of progenitors are directed by signals that come from the bone marrow microenvironment. Considerable knowledge has been gained on the murine hematopoietic stem cell microenvironment, while less so on the
Helene Bjoerg Kristensen +7 more
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Frontiers in Cell and Developmental Biology, 2021 Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells.
Laura Mosteo +9 more
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Modeling the Bone Marrow Microenvironment to Better Understand the Pathogenesis, Progression, and Treatment of Hematological Cancers. [PDF]
Cancers (Basel)Despite significant advancements in understanding the pathogenesis and treatment of hematological malignancies, including leukemia and multiple myeloma, the majority of patients continue to experience poor long-term outcomes.
Skelding KA, Barry DL, Lincz LF.
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Obesity-Induced Changes in Bone Marrow Homeostasis
Frontiers in Endocrinology, 2020 Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic ...
Andrea Benova, Michaela Tencerova
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Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis. [PDF]
PLoS ONE, 2009 The bone-bone marrow interface is an area of the bone marrow microenvironment in which both bone remodeling cells, osteoblasts and osteoclasts, and hematopoietic cells are anatomically juxtaposed.
April S Chan +8 more
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The Bone Marrow Microenvironment in Waldenström Macroglobulinemia [PDF]
Clinical Lymphoma Myeloma and Leukemia, 2013 Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma characterized by widespread involvement of the bone marrow (BM). The BM microenvironment serves as not only a site for disease involvement, but it also appears that the interaction of WM cells with the BM is essential for the pathogenesis of WM.
Amit, Agarwal, Irene M, Ghobrial
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Bone marrow derived cells as endothelial precursors and the role of multi-potent progenitor cells in repairing ischaemic tissues. [PDF]
, 2007 PhDIntroduction: Atherosclerosis and its complications are a major cause of death and disability and it remains a major challenge to develop new therapies for patients with irreversible end organ damage and ongoing ischaemia.
Wragg, Andrew
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Experimental Hematology & Oncology, 2022 Background The bone marrow is the place of hematopoiesis with a microenvironment that supports lifelong maintenance of stem cells and high proliferation.
Lorenz Nierves +7 more
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