The bone marrow microenvironment – Home of the leukemic blasts [PDF]
Blood Reviews, 2017 Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow (BM). Ex-vivo AML exhibits a high level of spontaneous apoptosis.
Manar S Shafat +2 more
exaly +5 more sources
Inflammatory bone marrow microenvironment. [PDF]
Hematology, 2019 Self-renewing hematopoietic stem cells and their progeny, lineage-specific downstream progenitors, maintain steady-state hematopoiesis in the bone marrow (BM).
N. Leimkühler, R. Schneider
semanticscholar +3 more sources
The bone marrow microenvironment in Waldenstrom macroglobulinemia [PDF]
Therapeutic Advances in Hematology, 2011 Waldenstrom macroglobulinemia (WM) is a low-grade B-cell lymphoproliferative disorder characterized primarily by specific homing and growth of tumor cells within the bone marrow niches.
Ghayas Issa +10 more
core +5 more sources
The bone marrow microenvironment at single-cell resolution [PDF]
Nature, 2019 The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to stress are incompletely understood.
Anastasia N. Tikhonova +25 more
semanticscholar +3 more sources
Metabolic crosstalk between stromal and malignant cells in the bone marrow niche
Bone Reports, 2023 Bone marrow is the primary site of blood cell production in adults and serves as the source of osteoblasts and osteoclasts that maintain bone homeostasis.
Hernán A. Tirado +4 more
doaj +2 more sources
Targeted Approaches to Inhibit Sialylation of Multiple Myeloma in the Bone Marrow Microenvironment
Frontiers in Bioengineering and Biotechnology, 2019 Aberrant glycosylation modulates different aspects of tumor biology, and it has long been recognized as a hallmark of cancer. Among the different forms of glycosylation, sialylation, the addition of sialic acid to underlying oligosaccharides, is often ...
Alessandro Natoni +3 more
doaj +2 more sources
Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment [PDF]
Frontiers in OncologyBone is a common site of metastasis for lung cancer. The “seed and soil” hypothesis suggests that the bone marrow microenvironment (“soil”) may provide a conducive survival environment for metastasizing tumor cells (“seeds”).
Jian Li +4 more
doaj +2 more sources
Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia [PDF]
Genes and DiseasesThe immune microenvironment plays an important role in leukemia treatment. However, a specific single-cell profiling of the immune alteration in bone marrow of chronic myeloid leukemia (CML) patients is still lacking. We performed multi-level single-cell
Chenjian Zhuo +9 more
doaj +2 more sources
Mast cells in the bone marrow microenvironment. [PDF]
Front ImmunolThe bone marrow microenvironment provides the necessary signals for the development from hematopoietic stem cells into mast cell precursors. Once released in the bloodstream, mast cells quickly migrate to peripheral tissues where they complete their differentiation.
Ribatti D.
europepmc +4 more sources
Decline in IGF1 in the Bone Marrow Microenvironment Initiates Hematopoietic Stem Cell Aging
Cell Stem Cell, 2021 Summary Decline in hematopoietic stem cell (HSC) function with age underlies limited healthspan of our blood and immune systems. In order to preserve health into older age, it is necessary to understand the nature and timing of initiating events that ...
Kira Young +9 more
semanticscholar +1 more source