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Importance of bone marrow cell dose in bone marrow transplantation
Clinical Transplantation, 1992The importance of the size of the infused marrow cell dose (MCD) was investigated in 274 patients undergoing allogeneic BMT between 1975 and 1990. Among those, 65 had acute myelogenous leukemia (AML), 79 acute lymphoblastic leukemia (ALL), 58 chronic myelogenous leukemia (CML) and 25 severe aplastic anemia (SAA).
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Bone marrow-derived mesenchymal stem cells
Leukemia & Lymphoma, 2005Human mesenchymal stem cells (MSCs) contribute to the regeneration of mesenchymal tissues, and are essential in providing support for the growth and differentiation of primitive hemopoietic cells within the bone marrow microenvironment. Techniques are now available to isolate human MSCs and manipulate their expansion in vitro under defined culture ...
Kemp, KC, Hows, J, Donaldson, C
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Bone Marrow-Derived Dendritic Cells
2013While much is understood about dendritic cells and their role in the immune system, the study of these cells is critical to gain a more complete understanding of their function. Dendritic cell isolation from mouse body tissues can be difficult and the number of cells isolated small.
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Bone-marrow haematopoietic-stem-cell niches
Nature Reviews Immunology, 2006Adult stem cells hold many promises for future clinical applications and regenerative medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so far, but in vitro expansion has been unsuccessful, limiting the future therapeutic potential of these cells. Here we review recent progress in characterizing the composition of
Anne, Wilson, Andreas, Trumpp
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Bone marrow cells regenerate infarcted myocardium
Nature, 2001Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation ...
D, Orlic +11 more
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Bone marrow-derived cells and hypertension
Expert Review of Cardiovascular Therapy, 2010Although it is clear that inadequate perfusion underlies most of the organ dysfunction accounting for hypertension-related adverse outcomes, our understanding of the pathophysiologic mechanisms is still evolving. The most important approaches to improving vascular health include reducing injury to the vessel wall and enhancing mechanisms to repair ...
Ki E, Park, Carl J, Pepine
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Thymus Homing Clonogenic Bone Marrow Cells
1985The thymus plays a major role in guiding the maturation, differentiation and specificity of T cells (1–4), In the adult mouse, the thymus receives small numbers of T cell precursors from the bone marrow and exports to the periphery a large variety of cells that differ by their surface antigens and functions.
S, Ezine, I L, Weissman, R V, Rouse
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VERSATILE STEM CELLS IN BONE MARROW
The Lancet, 1982The question of whether there is a single pluripotent haemopoietic stem cell or a variety of stem cells each with a capacity for self-replication is still unresolved. Evidence from radiation-chimaeras and from patients with marrow grafts indicates that haemopoietic stem cells are not a homogeneous population.
J F, Loutit +3 more
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Bone Marrow Cells and Myocardial Regeneration
International Journal of Hematology, 2004Hematopoietic stem cell (HSC) plasticity and its clinical application have been studied profoundly in the past few years. Recent investigations indicate that HSC and other bone marrow stem cells can develop into other tissues. Because of the high morbidity and mortality of myocardial infarction and other heart disorders, myocardial regeneration is a ...
Fu-Sheng, Wang, Cathy, Trester
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Stem cells as bone marrow residents
Biology Bulletin, 2011In addition to being a source of hematopoietic and mesenchymal stromal cells, bone marrow is known to be the source of stem cell populations, which express pluripotential markers and are capable of differentiating into cells of three blastophyllums (ectoderm, mesoderm, and endoderm).
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