Results 61 to 70 of about 104,182 (257)

Gaucher Disease: A Case with Unexplained Splenomegaly

Journal of Islamic International Medical College, 2018
A 5 years old male child presented with fever, repeated chest infection, short stature and developmental delay.On examination; he had massively enlarged spleen measuring 10 cm below left costal margin.
Ahsan Ahmad Alvi , Ayesha Nayyar , Rabiah Asghar , Muhammad Nadeem Akbar Khan , Ayesha Elahi , Ammar Naqvi
doaj  

CAPACITY OF MONONUCLEAR CELLS OF PERIPHERAL BLOOD AND BONE MARROW OF PATIENTS WITH APLASTIC ANEMIA TO PRODUCE MULTI-COLONY-STIMULATING FACTOR - IL-3

Медицинская иммунология, 2014
. The capacity of mononuclear cells of peripheral blood and bone marrow of 36 patients with aplastic anemia to produce multi-colony-stimulating factor - IL-3 have been studied.
O. E. Rozanova
doaj   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

INCREASE OF DRUG RESISTANCE OF ACUTE MYELOID LEUKEMIA CELLS IN MULTICELLULAR AGGREGATES IN VITRO

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Therapeutic efficiency in treatment of acute myeloid leukemia (AML) ranges from 20 to 45%. One of the causes of the latter is a drug resistance acquired by leukemic cells under the influence of treatment with antitumor medicines.
S. G. Zakharov, A. K. Golenkov, T. A. Mitina, T. D. Lutskaya, K. A. Belousov, R. S. Fadeev, M. E. Solovieva, A. S. Senotov, V. S. Akatov   +8 more
doaj   +1 more source

Density Gradient Centrifugation Compromises Bone Marrow Mononuclear Cell Yield

PLoS ONE, 2012
Bone marrow mononuclear cells (BMNCs) are widely used in regenerative medicine, but recent data suggests that the isolation of BMNCs by commonly used Ficoll-Paque density gradient centrifugation (DGC) causes significant cell loss and influences graft function.
Claudia Pösel, Karoline Möller, Wenke Fröhlich, Isabell Schulz, Johannes Boltze, Daniel-Christoph Wagner   +5 more
openaire   +4 more sources

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone

Bone Reports, 2017
Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP) has been shown to induce pagetic osteoclasts ...
Kumaran Sundaram, Yuvaraj Sambandam, Srinivasan Shanmugarajan, D. Sudhaker Rao, Sakamuri V. Reddy   +4 more
doaj   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Heterogeneous populations of bone marrow stem cells--are we spotting on the same cells from the different angles?

Folia Histochemica et Cytobiologica, 2004
Accumulated evidence suggests that in addition to hematopoietic stem cells (HSC), bone marrow (BM) also harbors endothelial stem cells (ESC), mesenchymal stem cells (MSC), multipotential adult progenitor cells (MAPC), pluripotent stem cells (PCS) as well
Janina Ratajczak, Ryan Reca, Marcin Majka, Magda Kucia, Mariusz Z Ratajczak   +4 more
doaj   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source