Results 61 to 70 of about 104,627 (255)
Bone-marrow mononuclear cell therapy of severe ischemic heart failure
Comptes Rendus. Biologies, 2007 We describe cell therapy for severe ischemic heart failure using transendocardial injection of autologous bone-marrow-derived mononuclear cells. The treated patients had significantly less heart failure and angina, sustained significant improvement of pumping power, exercise capacity, cardiac muscle irrigation, and blood supply to the body.
Hans Fernando R, Dohmann +5 more
openaire +2 more sources
THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome
Advanced Science, EarlyView.The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong +16 more
wiley +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Gaucher Disease: A Case with Unexplained Splenomegaly
Journal of Islamic International Medical College, 2018 A 5 years old male child presented with fever, repeated chest infection, short stature and developmental delay.On examination; he had massively enlarged spleen measuring 10 cm below left costal margin.
Ahsan Ahmad Alvi , Ayesha Nayyar , Rabiah Asghar , Muhammad Nadeem Akbar Khan , Ayesha Elahi , Ammar Naqvi
doaj
Медицинская иммунология, 2014 . The capacity of mononuclear cells of peripheral blood and bone marrow of 36 patients with aplastic anemia to produce multi-colony-stimulating factor - IL-3 have been studied.
O. E. Rozanova
doaj +1 more source
Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress
Advanced Science, EarlyView.Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen +11 more
wiley +1 more source
INCREASE OF DRUG RESISTANCE OF ACUTE MYELOID LEUKEMIA CELLS IN MULTICELLULAR AGGREGATES IN VITRO
Alʹmanah Kliničeskoj Mediciny, 2016 Background: Therapeutic efficiency in treatment of acute myeloid leukemia (AML) ranges from 20 to 45%. One of the causes of the latter is a drug resistance acquired by leukemic cells under the influence of treatment with antitumor medicines.
S. G. Zakharov +8 more
doaj +1 more source
Density Gradient Centrifugation Compromises Bone Marrow Mononuclear Cell Yield
PLoS ONE, 2012 Bone marrow mononuclear cells (BMNCs) are widely used in regenerative medicine, but recent data suggests that the isolation of BMNCs by commonly used Ficoll-Paque density gradient centrifugation (DGC) causes significant cell loss and influences graft function.
Claudia Pösel +5 more
openaire +4 more sources
Advanced Science, EarlyView.We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar +4 more
wiley +1 more source
Bone Reports, 2017 Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP) has been shown to induce pagetic osteoclasts ...
Kumaran Sundaram +4 more
doaj +1 more source