Results 181 to 190 of about 309,126 (317)

Dexamethasone and Doxycycline Doped Nanoparticles Increase the Differentiation Potential of Human Bone Marrow Stem Cells. [PDF]

Pharmaceutics, 2022
Toledano-Osorio M, López-García S, Osorio R, Toledano M, García-Bernal D, Sánchez-Bautista S, Rodríguez-Lozano FJ.   +6 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Substrate topography-induced osteogenesis of bone marrow stem cells by reducing the chromatin accessibility of YBX1. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Lv Y, Dai W, Zhang H, Liu S, Liu M, Zhang X, Li L, Hu Y, Liu Y, Song L.   +9 more
europepmc   +1 more source

Compromised osteogenic effect of exosomes internalized by senescent bone marrow stem cells via endocytoses involving clathrin, macropinocytosis and caveolae. [PDF]

Front Bioeng Biotechnol, 2022
Qi L, Ge W, Pan C, Jiang W, Lin D, Zhang L.   +5 more
europepmc   +1 more source

Tracing cell lineages in health and disease: experimental and human studies

, 2010
PhDThis study aimed to investigate stem cell biology in the normal and diseased pancreas and liver employing robust methods for tracking stem cells and their progeny in both pre-clinical and human scenario.
Lin, Wey-Ran
core  

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Assessing bone regeneration potential of 3D scaffold-free cell pellets from periodontal ligament and bone marrow stem cells. [PDF]

BMC Biotechnol
Liang X, Gong Y, Bai L, Ahmadi S, Yu M, Zhang Z, Fang S, Xu F, Wang W, Tu J, Na S.   +10 more
europepmc   +1 more source

Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells. [PDF]

Cell Discov, 2023
Ghanam J, Chetty VK, Anchan S, Reetz L, Yang Q, Rideau E, Liu X, Lieberwirth I, Wrobeln A, Hoyer P, Reinhardt D, Thakur BK.   +11 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

KLF5 Regulation of Exosome-Derived miR-152-3p From Bone Marrow Stem Cells Improves Ventricular Arrhythmia After Myocardial Infarction. [PDF]

Stem Cells Int
Wu C, Zou XY, Jiang YW, Lin DW, Jiang F, Wang YS.   +5 more
europepmc   +1 more source