Results 101 to 110 of about 1,454,464 (291)

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Impact of germline predisposition genes to hematologic malignancies on transplant outcomes and donor selection

Frontiers in Immunology
IntroductionGermline predisposition gene mutations may influence outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT).MethodsThis retrospective study of 558 patients undergoing HSCT (allo-HSCT in 557 cases, auto-HSCT in 1 case ...
Zhihui Li, Keyan Yang, Caiyan Zhang, Xianxuan Wang, Lei Wang, Jing Li, Xiaopei Wen, Qian Fei, Jiahong Zhai, Yan Zhou, Zongyang Ming, Yanzhi Song, Yongqiang Zhao, Tong Wu, Qinlong Zheng   +14 more
doaj   +1 more source

Oral cryotherapy to prevent total parenteral nutrition for patients undergoing bone marrow transplantation

, 2006
Introduction: Mucositis is a major complication in intensive chemotherapy, which often necessitates total parenteral nutrition (TPN). While the side effects of the conditioning regimes vary with regard to degree of severity among individual’s and between
Svanberg, Anncarin,, Birgegård, Gunnar, Öhrn, Kerstin,   +2 more
core  

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

The conditional benefit of being alive and disease free at 2 years after transplant: a long term survival evaluation among 456 patients affected by acute myeloid leukemia

Frontiers in Immunology
Risk factors for relapse and non-relapse mortality (NRM) in the first years after allogeneic hematopoietic stem cells transplant (allo-HSCT) for acute myeloid leukemia (AML) are well known, but their correlation with long-term survivorship is unclear ...
Alessandro Bruno, Francesca Lorentino, Matteo G. Carrabba, Sara Mastaglio, Raffaella Greco, Sarah Marktel, Simona Piemontese, Magda Marcatti, Luca Vago, Luca Vago, Francesca Farina, Daniela Clerici, Elisa Diral, Lorenzo Lazzari, Edoardo Campodonico, Daniele Sannipoli, Andrea Assanelli, Consuelo Corti, Massimo Bernardi, Jacopo Peccatori, Fabio Ciceri, Fabio Ciceri, Maria Teresa Lupo-Stanghellini   +22 more
doaj   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

PB2467: ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN 39 PATIENTS WITH NON-HODGKIN LYMPHOMA: LONG-TERM FOLLOW-UP IN A SINGLE CENTRE

HemaSphere, 2023
Fouzia Louar, Malek Benakli, Sabrina Akhrouf, Farih Mehdid, Nadia Rahmoune, Mounira Baazizi, Dina Ait Ouali, Hanane Bouarab, Sara Zerkout, Rihab Benouattas, Rose-Marie Hamladji, Redhouane Ahmed Nacer   +11 more
doaj   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source