Results 111 to 120 of about 1,371,434 (244)
Experimental Hematology & OncologyAlthough the efficacy of chimeric antigen receptor (CAR)-T cell therapy has been widely demonstrated, its clinical application is hampered by the complexity and fatality of its side effects.
Linqin Wang +13 more
doaj +1 more source
Advanced Science, EarlyView.Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan +9 more
wiley +1 more source
, 2008 Bone marrow transplantation (BMT) has been used for a wide variety of lysosomal storage diseases with encouraging results. We report a 3-year 5- month-old girl with Niemann- Pick type C disease (NPC) who received an allogeneic BMT, The patient presented ...
HSU, Y-S;HWU, WUH-LIANG;LU, MENG-YAO;CHEN, RONG-LONG;LIN, DONG-TSAMN;PENG, SHINN-FORNG;LIN, KAI-HSIN +1 more
core
, 1998 Relapse of chronic myeloid leukemia (CML) as extramedullary granulocytic sarcoma (GS) after allogeneic bone marrow transplantation (BMT) is a rare occurrence.
So, JCC +5 more
core +1 more source
Advanced Science, EarlyView.HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng +10 more
wiley +1 more source
Oral Compliacation after Bone Marrow Transplantation
, 2011 The bone marrow transplantation is a curative method in leukemia, lymphomas, immunodeficient states and solid tumors. Graft versus host disease (GVHD) is a significant complication in patients after bone marrow transplantion, most frequently affected of ...
K. Indrák +9 more
core +1 more source
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
wiley +1 more source
Advanced Science, EarlyView.Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao +7 more
wiley +1 more source