Results 121 to 130 of about 823,617 (410)

Suppressed Accumulation of Cerebral Amyloid β Peptides in Aged Transgenic Alzheimer’s Disease Mice by Transplantation with Wild-Type or Prostaglandin E2 Receptor Subtype 2-Null Bone Marrow [PDF]

, 2010
C. Dirk Keene, Rubens Chang, Américo H. López-Yglesias, Bryan Richard Shalloway, Izabella Sokal, Xianwu Li, Patrick Reed, Lisa Keene, Kathleen S. Montine, Richard Breyer, Jason K. Rockhill, Thomas J. Montine   +11 more
openalex   +1 more source

Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma.

New England Journal of Medicine, 1995
T. Philip, C. Guglielmi, A. Hagenbeek, Renier Somers, H. van der Lelie, D. Bron, P. Sonneveld, C. Gisselbrecht, J. Cahn, J. Harousseau, B. Coiffier, P. Biron, F. Mandelli, F. Chauvin   +13 more
semanticscholar   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

Signal Transduction and Targeted Therapy
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T (CAR-T) cells. MEK1/2 inhibitors (MEKIs), widely used in cancer treatment due to
Xiujian Wang, Xiao Tao, Pengjie Chen, Penglei Jiang, Wenxiao Li, Hefeng Chang, Cong Wei, Xinyi Lai, Hao Zhang, Yihan Pan, Lijuan Ding, Zuyu Liang, Jiazhen Cui, Mi Shao, Xinyi Teng, Tianning Gu, Jieping Wei, Delin Kong, Xiaohui Si, Yingli Han, Huarui Fu, Yu Lin, Jian Yu, Xia Li, Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang   +27 more
doaj   +1 more source

Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases.

Blood, 1998
S. Slavin, A. Nagler, E. Naparstek, Yossi Kapelushnik, M. Aker, G. Cividalli, G. Váradi, M. Kirschbaum, A. Ackerstein, S. Samuel, A. Amar, C. Brautbar, O. Ben‐Tal, A. Eldor, R. Or   +14 more
semanticscholar   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Autologous bone marrow transplantation for acute myeloid leukemia using busulfan plus etoposide as a preparative regimen [PDF]

, 1993
CA Linker, CA Ries, LE Damon, HS Rugo, JL Wolf   +4 more
openalex   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Treatment of pediatric acute lymphoblastic leukemia in India on BFM 95 protocol backbone with relevant modifications and minimal residual disease application - Doable and effective

Pediatric Hematology Oncology Journal, 2022
Dhwanee Thakkar, K. Upasana, Sunisha Arora, Ritu Chadha, D.S. Udayakumar, Bhawna Jha, Anjali Yadav, Neha Rastogi, Shalini Goel, Renu Saxena, Satya Prakash Yadav   +10 more
doaj   +1 more source

Reduced expression of vascular cell adhesion molecule-1 on bone marrow stromal cells isolated from marrow transplant recipients correlates with a reduced capacity to support human B lymphopoiesis in vitro [PDF]

, 1995
BN Dittel, Tucker W. LeBien
openalex   +1 more source