Results 131 to 140 of about 823,617 (410)
A Prospective, Randomized Trial of Autologous Bone Marrow Transplantation and Chemotherapy in Multiple Myeloma
, 1996 M. Attal, J. Harousseau, A. Stoppa, J. Sotto, J. Fuzibet, J. Rossi, P. Casassus, H. Maisonneuve, T. Facon, N. Ifrah, C. Payen, R. Bataille +11 moresemanticscholar +1 more sourcePBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC
Advanced Science, EarlyView.PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang +14 morewiley +1 more sourceHLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide.
Biology of Blood and Marrow Transplantation, 2008 L. Luznik, P. O'Donnell, H. Symons, Allen R. Chen, M. S. Leffell, M. Zahurak, Ted A Gooley, S. Piantadosi, M. Kaup, R. Ambinder, C. Huff, W. Matsui, J. Bolaños-Meade, I. Borrello, Jonathan Powell, Elizabeth Harrington, Sandra L. Warnock, Mary E. D. Flowers, R. Brodsky, B. Sandmaier, R. Storb, Richard J. Jones, E. Fuchs +22 moresemanticscholar +1 more sourceCleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang +13 morewiley +1 more sourceAssociation between Activated Partial Thromboplastin Time and the Amount of Infused Heparin at Bone Marrow Transplantation
, 2018 Machiko Kusuda, Shun‐ichi Kimura, Yukiko Misaki, Kazuki Yoshimura, Ayumi Gomyo, J. Hayakawa, Masaharu Tamaki, Yu Akahoshi, Tomotaka Ugai, Kazuaki Kameda, Hidenori Wada, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Miki Sato, Kiriko Terasako‐Saito, Misato Kikuchi, Hideki Nakasone, Shinichi Kako, Aki Tanihara, Yoshinobu Kanda +20 moreopenalex +1 more sourceDiscovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan +19 morewiley +1 more sourceBuilding blocks of hematology in the last 3 decades in Pakistan
Blood Advances, 2019 Tahir S. Shamsi, Tasneem Farzana, Saqib Ansari, Nazli Hossain, Arshi Naz, Munira Borhany, Mehwesh Taj, Saima Munzir, Uzma Zaidi, Jawwad Hassan, Nida Irfan, Nazmeen Shakoor, Farah Mubarak, Kouser Parveen, Syeda Anwari, Nadeem Ahmed, Mansoor Hussain, Irfan Ghafoor Baig, Dilnasheen Safdar, Sadaf Shahab +19 moredoaj +1 more sourcePB1967: EVALUATION OF A TRIAL OF IMATIB* DOSE TAPERING IN THE TREATMENT OF CHRONIC MYELOID LEUKEMIA IN CHRONIC PHASE: RESULTS AT 4.5 YEARS
HemaSphere, 2023 Naima Abdennebi, Fateh Boukhemia, Farida Harieche, Nacera Ait Amer, Farida Tensaout, Hanane Moussaoui, Sabrina Akhrouf, Malek Benakli, Rose-Marie Hamladji, Redhouane Ahmed-Nacer +9 moredoaj +1 more source
