Results 11 to 20 of about 672,142 (313)

New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism, but not in suckling [PDF]

, 2012
The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XLαs, XLN1, and ALEX or a double dose of maternally expressed Gsα to phenotype has not been ...
Abramowitz J, Balthasar N, Bamshad M, Bartness TJ, Bastepe M, Bastepe M, Baxendale RW, Bunting M, Castrop H, Cattanach BM, Cattanach BM, Chen M, Chen M, Chen M, Chotalia M, Crawford JA, de Bovis B, de Paula FJ, Ducy P, Elefteriou F, Friedman JM, Fu L, Fukao M, Germain-Lee EL, Hayward BE, Holmes R, Ivanova E, Kawai M, Kaya AI, Kehlenbach RH, Kelly ML, Kelsey G, Klemke M, Klemke M, Kublaoui BM, Lam DD, Liu J, Maffei M, Moore T, Oswal A, Pasolli HA, Pasolli HA, Peters J, Peters J, Peters J, Plagge A, Plagge A, Sakamoto A, Sakamoto A, Schmidt-Nielsen K, Shin JY, Shrestha YB, Skinner JA, Sleutels F, Storck T, Weinstein LS, Weinstein LS, Williamson CM, Williamson CM, Williamson CM, Wroe SF, Xie T, Yadav VK, Youngstrom TG, Yu S, Yu S   +65 more
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A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva

Orphanet Journal of Rare Diseases, 2023
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification.
Hayley Wallace, Rhonda H. Lee, Edward C. Hsiao   +2 more
doaj   +1 more source

Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency [PDF]

, 1997
Adults with childhood onset GH deficiency (GHD) have reduced bone mass, increased fat mass, and disorders of lipid metabolism. The aim of the present study was to evaluate bone mineral density (BMD), bone metabolism, body ...
Boerma, G.J.M. (Geert), Boot, A.M. (Annemieke), Engels, M.A. (Melanie), Krenning, E.P. (Eric), Muinck Keizer-Schrama, S.M.P.F. (Sabine) de   +4 more
core   +3 more sources

Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts

Journal of Functional Biomaterials, 2023
Calcium silicate-based cements are used in a variety of clinical conditions affecting the pulp tissue, relying on their inductive effect on tissue mineralization.
Gabriel Kato, Rita Araújo, Cláudia Rodrigues, Pedro Sousa Gomes, Liliana Grenho, Maria Helena Fernandes   +5 more
doaj   +1 more source

Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial. [PDF]

, 2017
Epidemiologic studies have demonstrated an association of elevated plasma homocysteine levels with greater bone resorption and fracture risk. Vitamins B12 , B6 , and folic acid are cofactors in homocysteine metabolism, and supplementation with B vitamins
Bauer, Douglas C, Christen, William G, Cummings, Steven R, Kado, Deborah, Lui, Li-Yung, Manson, JoAnn E, Schambach, Christopher, Stone, Katie L, Troen, Aron M   +8 more
core   +1 more source

The unsolved case of “bone-impairing analgesics”. The endocrine effects of opioids on bone metabolism [PDF]

, 2015
The current literature describes the possible risks for bone fracture in chronic analgesics users. There are three main hypotheses that could explain the increased risk of fracture associated with central analgesics, such as opioids: 1) the increased ...
COLUZZI, FLAMINIA, MATTIA, Consalvo, Pergolizzi, Joseph, Raffa, Robert B   +3 more
core   +3 more sources

Betaine promotes cell differentiation of human osteoblasts in primary culture

Journal of Translational Medicine, 2017
Background Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth factor I (IGF-I). The processes of
Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi, Ileana Terruzzi   +10 more
doaj   +1 more source

CDK12: A Potent Target and Biomarker for Human Cancer Therapy

Cells, 2020
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription.
Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian   +6 more
doaj   +1 more source

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Breast Cancer Research, 2019
Background Late-stage breast cancer preferentially metastasises to bone; despite advances in targeted therapies, this condition remains incurable.
Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell   +11 more
doaj   +1 more source

Acacetin Prevents Bone Loss by Disrupting Osteoclast Formation and Promoting Type H Vessel Formation in Ovariectomy-Induced Osteoporosis

Frontiers in Cell and Developmental Biology, 2022
Osteoporosis, characterized by the destruction of bone resorption and bone formation, is a serious disease that endangers human health. Osteoporosis prevention and treatment has become one of the important research contents in the field of medicine ...
Xiao Lin, Fang Xu, Ke-Wen Zhang, Wu-Xia Qiu, Hui Zhang, Qiang Hao, Meng Li, Xiao-Ni Deng, Ye Tian, Zhi-Hao Chen, Ai-Rong Qian   +10 more
doaj   +1 more source