Results 31 to 40 of about 2,226,476 (263)

Differential regulation of TNF-α and IL-1β production from endotoxin stimulated human monocytes by phosphodiesterase inhibitors

Mediators of Inflammation, 1992
The effect of selective PDE-I (vinpocetine), PDE-III (milrinone, CI-930), PDE-IV (rolipram, nitroquazone), and PDE-V (zaprinast) isozyme inhibitors on TNF-α and IL-1β production from LPS stimulated human monocytes was investigated.
K. L. Molnar-Kimber, L. Yonno, R. J. Heaslip, B. M. Weichman   +3 more
doaj   +1 more source

Transfer RNAs-derived small RNAs and their application potential in multiple diseases

Frontiers in Cell and Developmental Biology, 2022
The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which tRNA outstands by its role of the cellular ...
Xiaohua Chu, Chenyang He, Bo Sang, Chaofei Yang, Chong Yin, Mili Ji, Airong Qian, Ye Tian   +7 more
doaj   +1 more source

Bone Metabolism and RANKL/OPG Ratio in Rheumatoid Arthritis Women Treated with TNF-α Inhibitors

, 2021
The aim of this study was to evaluate the effect of anti-tumor necrosis factor α (anti-TNF-α) therapy in combination with methotrexate on bone remodeling and osteoclastogenesis in female patients with RA.
Anna Szeremeta, Agnieszka Jura-Półtorak, Krystyna Olczyk, Katarzyna Komosińska-Vassev, Aleksandra Zoń-Giebel   +4 more
core   +1 more source

MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1

Biology Open, 2020
Microtubule actin crosslinking factor 1 (MACF1) is a widely expressed cytoskeletal linker and plays an essential role in various cells’ functions by mediating cytoskeleton organization and dynamics.
Peihong Su, Chong Yin, Dijie Li, Chaofei Yang, Xue Wang, Jiawei Pei, Ye Tian, Airong Qian   +7 more
doaj   +1 more source

Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map

Frontiers in Endocrinology, 2022
Several physiological and pathological conditions such as aging, obesity, diabetes, anorexia nervosa are associated with increased adipogenesis in the bone marrow.
Shuang Zhang, Nicholas Lyons, Marijke Koedam, Jeroen van de Peppel, Johannes P.T.M. van Leeuwen, Bram C. J. van der Eerden   +5 more
doaj   +1 more source

Bone mineralisation and glucose metabolism. [PDF]

, 2023
Recent advancements in the bone biology field have identified a novel bone-metabolism axis. In this review we highlight several novel studies that further our knowledge of new endocrine functions of bone; explore remaining unanswered questions; and ...
MacRae, Vicky E., Roberts, Fiona L., MacRae, Vicky, Roberts, Fiona L, Roberts, Fiona L.,, MacRae, Vicky E.,, Lund University., Vicky E. MacRae, Fiona L. Roberts   +8 more
core   +1 more source

Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation

Cells, 2020
Microtubule actin crosslinking factor 1 (MACF1) is a large crosslinker that contributes to cell integrity and cell differentiation. Recent studies show that MACF1 is involved in multiple cellular functions such as neuron development and epidermal ...
Fan Zhao, Xiaoli Ma, Wuxia Qiu, Pai Wang, Ru Zhang, Zhihao Chen, Peihong Su, Yan Zhang, Dijie Li, Jianhua Ma, Chaofei Yang, Lei Chen, Chong Yin, Ye Tian, Lifang Hu, Yu Li, Ge Zhang, Xiaoyang Wu, Airong Qian   +18 more
doaj   +1 more source

In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications [PDF]

, 2009
We describe herein some immunological properties of human fetal bone cells recently tested for bone tissue-engineering applications. Adult mesenchymal stem cells (MSCs) and osteoblasts were included in the study for comparison.
Martin, I, Arnaud Scherberich, Montjovent, MO, Scherberich, A, Scherberich, Arnaud, Lee Ann Applegate, Montjovent, Marc-Olivier, Marc-Olivier Montjovent, Scaletta, Corinne, Dominique P. Pioletti, Bocelli-Tyndall, Chiara, Martin, Ivan, Applegate, LA, Laurent-Applegate, Lee, Bocelli-Tyndall, C., Pioletti, DP, Scherberich, A., Silke Mark, Montjovent, M.O., Scaletta, C, Pioletti, Dominique P., Mark, Silke, Mark, S., Bocelli-Tyndall, C, Applegate, Lee Ann, Mark, S, Pioletti, D.P., Corinne Scaletta, Scaletta, C., Ivan Martin, Martin, I., Applegate, L.A., Chiara Bocelli-Tyndall, Applegate LA, Pioletti DP, Mark S, Martin I, Bocelli-Tyndall C, Montjovent MO, Scaletta C, Scherberich A, Montjovent, Marc-Oliver   +41 more
core   +2 more sources

Effects of Probiotics and Gut Microbiota on Bone Metabolism in Chickens: A Review

, 2022
Broiler leg diseases are a common abnormal bone metabolism issue that leads to poor leg health in growing poultry. Bone metabolism is a complicated regulatory process controlled by genetic, nutritional, feeding management, environmental, or other ...
Liu, Kaili, Aftab Shaukat, Pan Chen, Shucheng Huang, Tingting Xu, Xu, Tingting, Zhang, Chaodong, Kaili Liu, Huang, Shucheng, He, Yanfeng, Chen, Pan, Yanfeng He, Shaukat, Aftab, Tong, Xishuai, Xishuai Tong, Chaodong Zhang   +15 more
core   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source