Results 51 to 60 of about 366,647 (265)
Cytokines and Bone Metabolism.
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1998 骨は構造体としての強度と構造を保持しつつ, 体内カルシウムの最大の貯蔵庫としての機能を維持するため, 常に活発な再構築を営んでいる. この骨代謝の動的平衡は, 各種の全身性ホルモンやその影響下で産生される局所性サイトカインに加え, 骨形成に携わる骨芽細胞系細胞と骨吸収に携わる破骨細胞系細胞との間の細胞-細胞間, あるいは細胞と基質との間の細胞-基質間相互作用などにより緻密な調節を受けている. 骨吸収を営む破骨細胞は血液系幹細胞に由来する多核の巨細胞で, 骨芽細胞との接触下で種々のサイトカインなどの作用により破骨細胞へと分化する. この過程の各段階で多様な転写因子が関与していることが明らかとなってきた.
Matsumoto, Toshio, Inoue, Daisuke
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
PPARs and Bone Metabolism [PDF]
PPAR Research, 2006 Welcome to the inaugural special issue of PPAR Research: PPARs and Bone Metabolism. In addition to the key roles PPARs play in numerous processes including glucose and fat metabolism, inflammation, cancer, and central nervous system maintenance, a new role for PPAR-γ has recently emerged: the maintenance of bone homeostasis during aging and disease. In
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Applied SciencesThis study aims to compare the effectiveness of ultrasonically and sonically activated irrigation in terms of extrusion risk, root canal debridement, and biofilm removal, considering distinct apical preparation sizes, through an ex vivo study in human ...
Sara Paixão +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Cells, 2020 Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously expressed P2X receptor in mammals and is positively associated with tumorigenesis in ...
Jiepei He +9 more
doaj +1 more source