Results 11 to 20 of about 366,647 (265)

Obesity and bone metabolism [PDF]

Hormones, 2018
The interaction between obesity and bone metabolism is complex. The effects of fat on the skeleton are mediated by both mechanical and biochemical factors. Though obesity is characterized by higher bone mineral density, studies conducted on bone microarchitecture have produced conflicting results.
Savvidis, Christos, Tournis, Symeon, Dede, Anastasia D.   +2 more
openaire   +3 more sources

A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva

Orphanet Journal of Rare Diseases, 2023
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification.
Hayley Wallace, Rhonda H. Lee, Edward C. Hsiao   +2 more
doaj   +1 more source

Adenosine and bone metabolism [PDF]

Trends in Endocrinology & Metabolism, 2013
Bone is a dynamic organ that undergoes continuous remodeling while maintaining a balance between bone formation and resorption. Osteoblasts, which synthesize and mineralize new bone, and osteoclasts, the cells that resorb bone, act in concert to maintain bone homeostasis.
Aránzazu, Mediero, Bruce N, Cronstein
openaire   +2 more sources

Betaine promotes cell differentiation of human osteoblasts in primary culture

Journal of Translational Medicine, 2017
Background Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth factor I (IGF-I). The processes of
Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi, Ileana Terruzzi   +10 more
doaj   +1 more source

Polymethoxyflavones and Bone Metabolism. [PDF]

Nutrients
Phytochemicals, such as flavonoids, are bioactive compounds produced by plants, including citrus fruits, that exhibit antioxidant effects on mammalian cells and tissues. Polymethoxyflavones (PMFs) are a family of flavonoids found in the pulp and peel of citrus fruits, and have been reported to have potent antioxidant activity implicated in the ...
Hirata M, Tominari T, Matsumoto C, Kasuga U, Ikeda K, Miyaura C, Grundler FMW, Inada M.   +7 more
europepmc   +3 more sources

Energy Metabolism of Bone [PDF]

Toxicologic Pathology, 2017
Biological processes utilize energy and therefore must be prioritized based on fuel availability. Bone is no exception to this, and the benefit of remodeling when necessary outweighs the energy costs. Bone remodeling is important for maintaining blood calcium homeostasis, repairing micro cracks and fractures, and modifying bone structure so that it is ...
Katherine J. Motyl, Anyonya R. Guntur, Adriana Lelis Carvalho, Clifford J. Rosen   +3 more
openaire   +2 more sources

CDK12: A Potent Target and Biomarker for Human Cancer Therapy

Cells, 2020
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription.
Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian   +6 more
doaj   +1 more source

Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts

Journal of Functional Biomaterials, 2023
Calcium silicate-based cements are used in a variety of clinical conditions affecting the pulp tissue, relying on their inductive effect on tissue mineralization.
Gabriel Kato, Rita Araújo, Cláudia Rodrigues, Pedro Sousa Gomes, Liliana Grenho, Maria Helena Fernandes   +5 more
doaj   +1 more source

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Breast Cancer Research, 2019
Background Late-stage breast cancer preferentially metastasises to bone; despite advances in targeted therapies, this condition remains incurable.
Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell   +11 more
doaj   +1 more source

Acacetin Prevents Bone Loss by Disrupting Osteoclast Formation and Promoting Type H Vessel Formation in Ovariectomy-Induced Osteoporosis

Frontiers in Cell and Developmental Biology, 2022
Osteoporosis, characterized by the destruction of bone resorption and bone formation, is a serious disease that endangers human health. Osteoporosis prevention and treatment has become one of the important research contents in the field of medicine ...
Xiao Lin, Fang Xu, Ke-Wen Zhang, Wu-Xia Qiu, Hui Zhang, Qiang Hao, Meng Li, Xiao-Ni Deng, Ye Tian, Zhi-Hao Chen, Ai-Rong Qian   +10 more
doaj   +1 more source