Results 11 to 20 of about 383,988 (266)

HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis

Stem Cell Research & Therapy, 2023
Background Recent evidence suggests that accumulation of marrow adipose tissue induced by aberrant lineage allocation of bone marrow-derived mesenchymal stromal cells (BMSCs) contributes to the pathophysiologic processes of osteoporosis.
Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerden   +4 more
doaj   +1 more source

Kidney Recovery in Patients With Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation FacilitiesPlain-Language Summary

Kidney Medicine, 2021
Rationale & Objective: Since January 2017, patients with acute kidney injury requiring dialysis (AKI-D) can be discharged to outpatient dialysis centers for continued hemodialysis (HD) support. We aimed to examine the rate of kidney recovery, time to
Melissa Jordan, Victor Ortiz-Soriano, Aaron Pruitt, Lauren Chism, Lucas J. Liu, Nourhan Chaaban, Madona Elias, B. Peter Sawaya, Jin Chen, Javier A. Neyra   +9 more
doaj   +1 more source

A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva

Orphanet Journal of Rare Diseases, 2023
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification.
Hayley Wallace, Rhonda H. Lee, Edward C. Hsiao   +2 more
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Betaine promotes cell differentiation of human osteoblasts in primary culture

Journal of Translational Medicine, 2017
Background Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth factor I (IGF-I). The processes of
Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi, Ileana Terruzzi   +10 more
doaj   +1 more source

CDK12: A Potent Target and Biomarker for Human Cancer Therapy

Cells, 2020
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription.
Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian   +6 more
doaj   +1 more source

Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts

Journal of Functional Biomaterials, 2023
Calcium silicate-based cements are used in a variety of clinical conditions affecting the pulp tissue, relying on their inductive effect on tissue mineralization.
Gabriel Kato, Rita Araújo, Cláudia Rodrigues, Pedro Sousa Gomes, Liliana Grenho, Maria Helena Fernandes   +5 more
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Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Breast Cancer Research, 2019
Background Late-stage breast cancer preferentially metastasises to bone; despite advances in targeted therapies, this condition remains incurable.
Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell   +11 more
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Acacetin Prevents Bone Loss by Disrupting Osteoclast Formation and Promoting Type H Vessel Formation in Ovariectomy-Induced Osteoporosis

Frontiers in Cell and Developmental Biology, 2022
Osteoporosis, characterized by the destruction of bone resorption and bone formation, is a serious disease that endangers human health. Osteoporosis prevention and treatment has become one of the important research contents in the field of medicine ...
Xiao Lin, Fang Xu, Ke-Wen Zhang, Wu-Xia Qiu, Hui Zhang, Qiang Hao, Meng Li, Xiao-Ni Deng, Ye Tian, Zhi-Hao Chen, Ai-Rong Qian   +10 more
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Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles

Genome Medicine, 2023
Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo.
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu   +9 more
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Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice

Mediators of Inflammation, 1992
Collagen-induced arthritis (CIA) is an immunologically relevant animal model of human rheumatoid arthritis. Studies comparing the disease incidence in genetically susceptible male and female DBA/1LacJ mice demonstrated that under low density/low stress ...
Robert G. Caccese, John L. Zimmerman, Richard P. Carlson   +2 more
doaj   +1 more source