Results 21 to 30 of about 383,988 (266)

Differential regulation of TNF-α and IL-1β production from endotoxin stimulated human monocytes by phosphodiesterase inhibitors

Mediators of Inflammation, 1992
The effect of selective PDE-I (vinpocetine), PDE-III (milrinone, CI-930), PDE-IV (rolipram, nitroquazone), and PDE-V (zaprinast) isozyme inhibitors on TNF-α and IL-1β production from LPS stimulated human monocytes was investigated.
K. L. Molnar-Kimber, L. Yonno, R. J. Heaslip, B. M. Weichman   +3 more
doaj   +1 more source

Antimicrobial Biomaterials for the Healing of Infected Bone Tissue: A Systematic Review of Microtomographic Data on Experimental Animal Models

Journal of Functional Biomaterials, 2022
Bone tissue infection is a major clinical challenge with high morbidity and a significant healthcare burden. Therapeutic approaches are usually based on systemic antibacterial therapies, despite the potential adverse effects associated with antibiotic ...
Lorena Castro Mariano, Maria Helena Raposo Fernandes, Pedro Sousa Gomes   +2 more
doaj   +1 more source

Role of cancer stem cells in the development of giant cell tumor of bone

Cancer Cell International, 2020
The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant tumor which exhibits localized dynamism and ...
Abdul Rouf War, Kai Dang, Shanfen Jiang, Zhongwei Xiao, Zhiping Miao, Tuanmin Yang, Yu Li, Airong Qian   +7 more
doaj   +1 more source

Sociodemographic factors affecting the disease acceptance in the group of women with postmenopausal osteoporosis

International Journal of Occupational Medicine and Environmental Health, 2021
Objectives Assessment of the disease acceptance level in women with osteoporosis depending on selected sociodemographic factors. Material and Methods The study included a group of 198 women, aged M±SD 72.3±8.59 years, diagnosed with postmenopausal ...
Bogumiła Górczewska, Elżbieta Jakubowska-Pietkiewicz   +1 more
doaj   +1 more source

Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map

Frontiers in Endocrinology, 2022
Several physiological and pathological conditions such as aging, obesity, diabetes, anorexia nervosa are associated with increased adipogenesis in the bone marrow.
Shuang Zhang, Nicholas Lyons, Marijke Koedam, Jeroen van de Peppel, Johannes P.T.M. van Leeuwen, Bram C. J. van der Eerden   +5 more
doaj   +1 more source

MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1

Biology Open, 2020
Microtubule actin crosslinking factor 1 (MACF1) is a widely expressed cytoskeletal linker and plays an essential role in various cells’ functions by mediating cytoskeleton organization and dynamics.
Peihong Su, Chong Yin, Dijie Li, Chaofei Yang, Xue Wang, Jiawei Pei, Ye Tian, Airong Qian   +7 more
doaj   +1 more source

Transfer RNAs-derived small RNAs and their application potential in multiple diseases

Frontiers in Cell and Developmental Biology, 2022
The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which tRNA outstands by its role of the cellular ...
Xiaohua Chu, Chenyang He, Bo Sang, Chaofei Yang, Chong Yin, Mili Ji, Airong Qian, Ye Tian   +7 more
doaj   +1 more source

Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation

Cells, 2020
Microtubule actin crosslinking factor 1 (MACF1) is a large crosslinker that contributes to cell integrity and cell differentiation. Recent studies show that MACF1 is involved in multiple cellular functions such as neuron development and epidermal ...
Fan Zhao, Xiaoli Ma, Wuxia Qiu, Pai Wang, Ru Zhang, Zhihao Chen, Peihong Su, Yan Zhang, Dijie Li, Jianhua Ma, Chaofei Yang, Lei Chen, Chong Yin, Ye Tian, Lifang Hu, Yu Li, Ge Zhang, Xiaoyang Wu, Airong Qian   +18 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

miR-129-5p Inhibits Bone Formation Through TCF4

Frontiers in Cell and Developmental Biology, 2020
Osteoporosis is a frequently occurring bone disease in middle-aged and aged men and women. However, current therapies on this disease are still not ideal.
Chong Yin, Ye Tian, Yang Yu, Chaofei Yang, Peihong Su, Yipu Zhao, Xue Wang, Kewen Zhang, Jiawei Pei, Dijie Li, Zhihao Chen, Yan Zhang, Zhiping Miao, Airong Qian   +13 more
doaj   +1 more source