Results 21 to 30 of about 366,647 (265)
Genome Medicine, 2023 Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo.
Randy B. Kang +9 more
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Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice
Mediators of Inflammation, 1992 Collagen-induced arthritis (CIA) is an immunologically relevant animal model of human rheumatoid arthritis. Studies comparing the disease incidence in genetically susceptible male and female DBA/1LacJ mice demonstrated that under low density/low stress ...
Robert G. Caccese +2 more
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Periodontitis and bone metabolism
Clinical Cases in Mineral and Bone Metabolism, 2015 Periodontitis is a plaque induced disease characterized by tissue destruction. The extent of the alveolar bone loss depends on the host response stimulated by bacterial infection. Recently researchers have focused on the role of the immune system, of RANK/RANKL/OPG pathway and of cytokines network.
Barbato L. +6 more
openaire +3 more sources
Journal of Functional Biomaterials, 2022 Bone tissue infection is a major clinical challenge with high morbidity and a significant healthcare burden. Therapeutic approaches are usually based on systemic antibacterial therapies, despite the potential adverse effects associated with antibiotic ...
Lorena Castro Mariano +2 more
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Role of cancer stem cells in the development of giant cell tumor of bone
Cancer Cell International, 2020 The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant tumor which exhibits localized dynamism and ...
Abdul Rouf War +7 more
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International Journal of Occupational Medicine and Environmental Health, 2021 Objectives Assessment of the disease acceptance level in women with osteoporosis depending on selected sociodemographic factors. Material and Methods The study included a group of 198 women, aged M±SD 72.3±8.59 years, diagnosed with postmenopausal ...
Bogumiła Górczewska +1 more
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Mediators of Inflammation, 1992 The effect of selective PDE-I (vinpocetine), PDE-III (milrinone, CI-930), PDE-IV (rolipram, nitroquazone), and PDE-V (zaprinast) isozyme inhibitors on TNF-α and IL-1β production from LPS stimulated human monocytes was investigated.
K. L. Molnar-Kimber +3 more
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Transfer RNAs-derived small RNAs and their application potential in multiple diseases
Frontiers in Cell and Developmental Biology, 2022 The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which tRNA outstands by its role of the cellular ...
Xiaohua Chu +7 more
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MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1
Biology Open, 2020 Microtubule actin crosslinking factor 1 (MACF1) is a widely expressed cytoskeletal linker and plays an essential role in various cells’ functions by mediating cytoskeleton organization and dynamics.
Peihong Su +7 more
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Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map
Frontiers in Endocrinology, 2022 Several physiological and pathological conditions such as aging, obesity, diabetes, anorexia nervosa are associated with increased adipogenesis in the bone marrow.
Shuang Zhang +5 more
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