Results 21 to 30 of about 2,226,476 (263)

The Role of Bone-Derived Hormones in Glucose Metabolism, Diabetic Kidney Disease, and Cardiovascular Disorders

open access: yes, 2022
Bone contributes to supporting the body, protecting the central nervous system and other organs, hematopoiesis, the regulation of mineral metabolism (mainly calcium and phosphate), and assists in respiration. Bone has many functions in the body. Recently,
Yuichi Takashi, Daiji Kawanami
core   +1 more source

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

open access: yesBreast Cancer Research, 2019
Background Late-stage breast cancer preferentially metastasises to bone; despite advances in targeted therapies, this condition remains incurable.
Diane Lefley   +11 more
doaj   +1 more source

Acacetin Prevents Bone Loss by Disrupting Osteoclast Formation and Promoting Type H Vessel Formation in Ovariectomy-Induced Osteoporosis

open access: yesFrontiers in Cell and Developmental Biology, 2022
Osteoporosis, characterized by the destruction of bone resorption and bone formation, is a serious disease that endangers human health. Osteoporosis prevention and treatment has become one of the important research contents in the field of medicine ...
Xiao Lin   +10 more
doaj   +1 more source

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles

open access: yesGenome Medicine, 2023
Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo.
Randy B. Kang   +9 more
doaj   +1 more source

Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice

open access: yesMediators of Inflammation, 1992
Collagen-induced arthritis (CIA) is an immunologically relevant animal model of human rheumatoid arthritis. Studies comparing the disease incidence in genetically susceptible male and female DBA/1LacJ mice demonstrated that under low density/low stress ...
Robert G. Caccese   +2 more
doaj   +1 more source

Subchronic dietary exposure of rats to cadmium alters the metabolism of metals essential to bone health [PDF]

open access: yes, 2004
Cadmium (Cd) was recently identified as a risk factor for osteoporosis. Skeletal damage may be the critical effect of low-level long-term exposure to Cd in the general population exposed via food, but the mechanisms behind this are not clearly understood.
M Kolf-Clauw   +5 more
core   +1 more source

Antimicrobial Biomaterials for the Healing of Infected Bone Tissue: A Systematic Review of Microtomographic Data on Experimental Animal Models

open access: yesJournal of Functional Biomaterials, 2022
Bone tissue infection is a major clinical challenge with high morbidity and a significant healthcare burden. Therapeutic approaches are usually based on systemic antibacterial therapies, despite the potential adverse effects associated with antibiotic ...
Lorena Castro Mariano   +2 more
doaj   +1 more source

Role of cancer stem cells in the development of giant cell tumor of bone

open access: yesCancer Cell International, 2020
The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant tumor which exhibits localized dynamism and ...
Abdul Rouf War   +7 more
doaj   +1 more source

Sociodemographic factors affecting the disease acceptance in the group of women with postmenopausal osteoporosis

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2021
Objectives Assessment of the disease acceptance level in women with osteoporosis depending on selected sociodemographic factors. Material and Methods The study included a group of 198 women, aged M±SD 72.3±8.59 years, diagnosed with postmenopausal ...
Bogumiła Górczewska   +1 more
doaj   +1 more source

The influence of growth hormone deficiency on bone health and metabolism

open access: yes, 2023
Growth hormone (GH) is a key peptide hormone in the regulation of bone metabolism, through its systemic and paracrine action mediated directly as well as by insulin-like growth factor-1 (IGF-1).
Jakub Wydra   +3 more
core   +1 more source

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