Results 71 to 80 of about 672,142 (313)

Noggin depletion in adipocytes promotes obesity in mice. [PDF]

, 2019
ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin ...
Blázquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guo, Yina, Jumabay, Medet, Lusis, Aldons J, Rajbhandari, Prashant, Reue, Karen, Sallam, Tamer, Tontonoz, Peter, Vergnes, Laurent, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng, Zhang, Li   +14 more
core   +1 more source

Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization [PDF]

, 2009
Initiation of mineralization during endochondral ossification is a multistep process and has been assumed to correlate with specific interactions of annexins A5 and A6 and collagens.
Anderson, Anja Niehoff, Balcerzak, Balcerzak, Belluoccio, Bent Brachvogel, Berendes, Blumbach, Brachvogel, Brachvogel, Brachvogel, Bradford, Budde, Christian Frie, Collett, Damazo, Daniele Belluoccio, DiCesare, Ernst Pöschl, Friedericke Pausch, Genge, Genge, Gerke, Girkontaite, Haut Donahue, Hawkins, Hazarika, Hikiji, Hofmann, Ivan Grskovic, John F Bateman, Julia Etich, Karsenty, Karsenty, Kim, Kirsch, Kirsch, Kirsch, Koopman, Kwan, Ling, Livak, Morgan, Murshed, Pfaffl, Rety, Romeis, Sabrina Rosenbaum, Schmitz, Srivastava, Srivastava, Stephen E Moss, Ursula Schlötzer-Schrehardt, Van Gelder, White   +54 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Exploring the Bone Proteome to Help Explain Altered Bone Remodeling and Preservation of Bone Architecture and Strength in Hibernating Marmots [PDF]

, 2016
Periods of physical inactivity increase bone resorption and cause bone loss and increased fracture risk. However, hibernating bears, marmots, and woodchucks maintain bone structure and strength, despite being physically inactive for prolonged periods ...
Broccardo, Carolyn J., Condon, Keith W., Doherty, Alison H., Donahue, Seth W., Florant, Gregory L., Gookin, Sara E., McGrew, Ashley K., Prenni, Jessica E., Roteliuk, Danielle M., Wojda, Samantha J.   +9 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone Influence Muscle Outcomes in Children and Adolescents [PDF]

, 2018
Increases in 25-hydroxyvitamin D concentrations are shown to improve strength in adults; however, data in pediatric populations are scant and equivocal. In this ancillary study of a larger-scale, multi-sited, double-blind, randomized, placebo-controlled ...
Addison, Bergman, Bignotti, Bischoff-Ferrari, Boland, Buford, Cangussu, Carrillo, Ceglia, Ceglia, Close, DeLuca, Dhesi, El-Hajj Fuleihan, El-Hajj Fuleihan, Foo, Gerdhem, Gilsanz, Girgis, Glendenning, Goodpaster, Goran, Goswami, Gupta, Hansen, Haroon, Hassan-Smith, Hoaglin, Houston, Keihan Rodrigues Matsudo, Kwon, Lewis, Looker, Malina, Mansbach, Michael, Miljkovic-Gacic, Molenaar, Neinstein, Passeri, Pate, Pollock, Redzic, Rittweger, Rogol, Sinha, Swinford, Tanner, Templeton, Visser, Ward, Ward, Warden, Wind, Wolff, Yin   +55 more
core   +2 more sources

Bone metabolism [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2021
openaire   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Adenosine Deaminase 2 Deficiency: Its pleiotropic manifestations may also affect bone metabolism? A case study on two homozygous female twins

Bone Reports, 2021
Erika Marin, Iacopo Chiodini, Luca Persani, Alberto Falchetti, Silvia Vai   +4 more
doaj   +1 more source

Comparative Evaluation of Ultrasonic and Sonic Irrigant Activation Systems: Assessing Extrusion Risk, Debridement, and Biofilm Removal in Distinct Apical Preparation Sizes

Applied Sciences
This study aims to compare the effectiveness of ultrasonically and sonically activated irrigation in terms of extrusion risk, root canal debridement, and biofilm removal, considering distinct apical preparation sizes, through an ex vivo study in human ...
Sara Paixão, Pedro Sousa Gomes, Maria Helena Fernandes, Cláudia Rodrigues, Liliana Grenho   +4 more
doaj   +1 more source