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Nature Reviews Disease Primers, 2020 Bone is the most frequent site for metastasis for many cancers, notably for tumours originating in the breast and the prostate. Tumour cells can escape from the primary tumour site and colonize the bone microenvironment. Within the bone, these disseminated tumour cells, as well as those arising in the context of multiple myeloma, may assume a state of ...
Peter I Croucher +2 more
exaly +7 more sources
Biology of Bone Metastases [PDF]
Cancer Control, 2012 Background Bone metastases cause morbidity and mortality in multiple malignancies. In addition to portending a dire prognosis, bone metastases cause bone pain, fractures, hypercalcemia, spinal cord compression, and other nerve compression syndromes ...
Richard L. Theriault +1 more
core +3 more sources
Bone metastases in biliary cancers: A multicenter retrospective survey [PDF]
, 2018 Natural history of biliary cancers metastatic to bone The role of skeletal events in patients with biliary cancer Biliary cancer and bone metastases: role of ...
S Lonardi +57 more
core +4 more sources
Oncology Reviews, 2017 Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be treated to slow its growth. The majority of skeletal metastases
Luísa Pinto +6 more
core +4 more sources
Electrochemotherapy Is Effective in the Treatment of Bone Metastases [PDF]
, 2022 Bone metastases induce pain, risk of fracture, and neural compression, and reduced mobility and quality of life. Electrochemotherapy (ECT) is a minimally invasive local treatment based on a high-voltage electric pulse combined with an anticancer drug ...
Davide Maria Donati +6 more
core +2 more sources
Cancer Epidemiology, 2014 Background: Bone is the most common metastatic site associated with breast cancer. Using a database of women with breast cancer treated at Guy's Hospital, London 1976-2006 and followed until end 2010, we determined incidence of and survival after bone ...
M Harries, S Kabilan, A Purushotham
exaly +2 more sources
Predicting the Risk for Pathological Fracture in Bone Metastases. [PDF]
Curr OncolApproximately 50–70% of patients with advanced cancer will experience bone metastases. The link between metastatic lesions and pathological bones is especially troubling since more metastases mean a higher chance of painful fractures, which can ...
Altsitzioglou P +4 more
europepmc +2 more sources
Editorial: Bone Metastases [PDF]
Frontiers in Oncology, 2021 No abstract ...
Valenti, Maria Teresa +3 more
openaire +5 more sources
Nursing Standard, 2013 This bachelor's thesis deals with the topic ?Bone metastases?. The topic is split into the theoretical and practical part. To understand better the whole topic, I describe in the theoretical part at first the general anatomy of the bone tissue ...
MELICHAROVÁ, Miroslava
core +2 more sources
Pathophysiology of bone metastases [PDF]
Cancer Biology & Therapy, 2006 Normal bone remodeling maintains an appropriate balance between the action of osteoclasts (bone-resorbing cells) and osteoblasts (bone-forming cells). Skeletal malignancies, including bone metastases, disrupt the OPG-RANKL-RANK signal transduction pathway and promote enhanced osteoclast formation, thereby accelerating bone resorption and inducing bone ...
James R, Berenson +2 more
openaire +2 more sources