Results 181 to 190 of about 2,076,755 (337)

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

Advanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang, Xiaoying Huang, Lingchuan Ma, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang‐Jiang Qin, Xiang Wang, Yuhong Cao, Kai Miao   +12 more
wiley   +1 more source

Bone metastases from endocrine cancer: advances in diagnosis, treatment, and prevention. [PDF]

Front Endocrinol (Lausanne)
Huang S, Shen Y, Li H, Geng T, Yan J, Wang L, Sui L.   +6 more
europepmc   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Bone Metastases of Breast Cancer in the Skull Base: An Unusual Metastatic Spread. [PDF]

Cureus
Beja MS, Marques J, Cardoso VS, Sidiropoulou Z.   +3 more
europepmc   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Analysis of the clinical characteristics of bone metastases after pheochromocytoma/paraganglioma surgery. [PDF]

Front Endocrinol (Lausanne)
Li L, Gao H, Shao Y, Zhu X.
europepmc   +1 more source

Experience of patients with advanced cancer undergoing palliative radiotherapy for bone metastases: A qualitative study

Akane Tsujimoto, Junko Kusunoki, Mariko Masujima   +2 more
openalex   +1 more source

High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial [PDF]

, 2015
Harald Rief, Sonja Katayama, Thomas Brückner, Stefan Rieken, Tilman Bostel, Robert Förster, Ingmar Schlampp, Robert Wolf, Jürgen Debus, Florian Sterzing   +9 more
openalex   +1 more source

Figure S5 from ERRα Expression in Bone Metastases Leads to an Exacerbated Antitumor Immune Response

, 2023
Mathilde Bouchet, Alexandra Lainé, Cyril Boyault, Mathilde Proponnet-Guérault, Emmanuelle Meugnier, Lamia Bouazza, Casina W.S. Kan, Sandra Geraci, Soumaya El-Moghrabi, Héctor Hernández‐Vargas, Claire Benetollo, Yuji Yoshiko, Martine Duterque‐Coquillaud, Philippe Clézardin, Julien C. Marie, Edith Bonnelye   +15 more
openalex   +1 more source

Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2017
A. Himelstein, Jared C. Foster, J. Khatcheressian, John D. Roberts, D. Seisler, P. Novotny, R. Qin, R. Go, S. Grubbs, T. O'Connor, M. Velasco, D. Weckstein, A. O'Mara, C. Loprinzi, C. Shapiro   +14 more
semanticscholar   +1 more source