Results 201 to 210 of about 241,339 (286)

Real‐Time In Vivo Visualization of Tumor‐Associated Macrophage Reprogramming Using a Nitric Oxide‐Activatable NIR‐II Nanoinducer

Advanced Science, EarlyView.
Reprogramming tumor‐associated macrophages is a promising therapeutic strategy for solid tumors. Here, a nitric oxide (NO)‐activatable NIR‐II fluorescence/photoacoustic nanoinducer (I/E@M2pep) that simultaneously facilitates and visualizes the repolarization of TAMs to an M1‐like phenotype is reported, thereby enhancing anti‐tumor efficacy through M1 ...
Qian Chen, Meng Li, Tuanwei Li, Chen Yang, Xiaohu Yang, Hongchao Yang, Yejun Zhang, Chunyan Li, Qiangbin Wang   +8 more
wiley   +1 more source

High incidence and poor prognosis of bone metastases in functioning small intestinal neuroendocrine tumors. [PDF]

Front Endocrinol (Lausanne)
Mathew A, Hauptmeier P, Schaarschmidt BM, Fendler WP, Führer D, Lahner H.   +5 more
europepmc   +1 more source

Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device: A multicenter retrospective study [PDF]

, 2014
Anchala, Praveen R, Brook, Allan, Coldwell, Douglass M, Friedman, Michael V, Georgy, Bassem A, Hillen, Travis J, Irving, Winston D, Jennings, Jack W, Tran, Nam D, Vrionis, Frank D   +9 more
core   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Bone metastases from neuroendocrine neoplasms: Results of an Italian nationwide survey of natural history and management. [PDF]

J Neuroendocrinol
Fazio N, Maisonneuve P, Frezza AM, Ranallo N, Ibrahim T, La Salvia A, Brizzi MP, De Divitiis C, Tafuto S, Pusceddu S, Marconcini R, Cives M, Ferrari C, Campana D, De Lisi D, Santini D, Faggiano A, Modica R, Massironi S, Bianchi A, Panzuto F, Antonuzzo L, Pellegrini E, Amoroso V, Puliafito I, Merola E, Silvestris N, Grana CM, Spada F.   +28 more
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Real-life use of bone-targeting agents for bone metastases in France between 2009 and 2018: Results of the OPTIMOS study. [PDF]

J Bone Oncol
Confavreux CB, Bouvard B, Girard N, Bosco-Levy P, Marchal C, Nolin M, Lehmann E, Desameric G, Belhassen M.   +8 more
europepmc   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Oxidation-activated nanotherapy boosts tumor immunity and disrupts tumor-nerve crosstalk to combat bone metastases and cancer pain. [PDF]

Sci Adv
Zhang Z, Chen P, Zheng Y, Li M, Zhao L, Fu Z, Zhou Y, Zhang T, Sun X, Zhu D, Shen Y, Fan S, Liu X, Xiang J.   +13 more
europepmc   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source