Results 261 to 270 of about 255,505 (337)

circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose‐derived stem cells via the hsa‐miR‐647/SOX9 pathway

Animal Models and Experimental Medicine, EarlyView.
The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou, Huajun Wang, Hao Guo, Dongbin Luo, Xiaofei Zheng, Simin Luo   +5 more
wiley   +1 more source

Risk factors for skeletal-related events in patients with stage IV lung adenocarcinoma and bone metastases receiving denosumab: a retrospective cohort analysis. [PDF]

Support Care Cancer
Zhang H, Wen D, Liao Z, Tan X, Wang H, Xiang J, Yan B.   +6 more
europepmc   +1 more source

Biocompatibility and healing patterns in experimentally induced canine tibial fractures using Pedicle screw‐Rod external fixation

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that using a Pedicle screw‐Rod configuration for the external fixation of non‐articular tibial osteotomy aligns well with the principles of biological osteosynthesis, resulting in secondary bone healing characterized by callus formation and neovascularization.
Mohammad Mahdi Gooran, Ramin Mazaheri‐Khameneh, Seyed Mohammad Hashemi‐Asl, Rahim Hobbenaghi   +3 more
wiley   +1 more source

OPG-Producing B Cells and RANKL-Expressing T Cells Define Immune Signatures Predictive of Bone Metastases in Breast Cancer. [PDF]

Cancer Res Commun
Monteiro AC, Garcia DD, Fontão APA, Du Rocher B, Globa Masset ME, Alves IN, Carvalho LG, Andrade CV, Fidalgo G, Colaço MV, Nogueira LP, Dias Gaui MF, Bonomo A.   +12 more
europepmc   +1 more source

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Bone metastases in advanced urothelial carcinoma patients receiving enfortumab vedotin: A Real-World study from the ARON-2^EV project. [PDF]

Clin Exp Med
Rizzo A, Myint ZW, Ciccimarra F, Zgura A, Matrana MR, Büttner T, Kopecky J, Vida AR, Rizzo M, Fujita K, Brunetti O, Santini D, Park SH, Formisano L, Poprach A, Kucharz J, Comes MC, Bove S, Fanizzi A, Massafra R, Cazzato G, Monteiro FSM, Mollica V, Massari F, Cerrillo JM, Santoni M.   +25 more
europepmc   +1 more source

Tumour cell-bone cell interactions in breast cancer bone metastases : mechanisms and effects of therapies

, 2012
Hannah K. Brown
openalex   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Comparative Efficacy and Cost-Effectiveness of Denosumab Versus Zoledronic Acid in Cancer Patients with Bone Metastases. [PDF]

J Clin Med
Aliyev V, Guliyev M, Günaltılı M, Fidan MC, Çerme E, Abbasov H, Birsin Z, Cebeci S, Demirci NS, Alan Ö.   +9 more
europepmc   +1 more source

Denosumab for Breast Cancer with Bone Metastases-Induced Hypercalcemia Complicated with Acute Renal Failure

, 2015
Chen‐Yu Kuo, Ta‐Chung Chao
openalex   +2 more sources