Results 111 to 120 of about 21,763 (267)

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Bone quality in vertebral fracture: Microdamage, mineralisation and microarchitecture of the cortical shell in lumbar vertebrae

, 2009
Resistance to vertebral fracture is provided by a bone structure that integrates the cortical shell, or cortex, with trabecular bone. The cortical shell of vertebral bodies demonstrates a contribution to load sharing that is disproportionate to its ...
Roux, JP, Bala, Y, Arlot, ME, Follet, H, Forwood, MR, Burt-Pitchat, B, Delmas, PD   +6 more
core  

Mapping Fatty Acid Composition in the Human Knee: Short‐Term Repeatability at 3T

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Alterations in periarticular lipid composition are implicated in musculoskeletal diseases, yet short‐term reliability of MRI‐based triglyceride composition mapping in the knee is not fully established. Purpose To evaluate 1‐week repeatability of proton‐density fat fraction (PDFF) and triglyceride fatty‐acid composition—saturated ...
Dimitri Martel, Anne Adlung, Baptiste Busi, Rollanda Bernadin, Yagni Shah, Thorsten Kirsch, Richard Kijowski, Guillaume Madelin, Amparo Ruiz   +8 more
wiley   +1 more source

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Journal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis, Kelly Galisteu‐Luiz, Gabriela Leite Pedroso, Gustavo Lopes Puls, Leticia Cassaro, Bruno Boaventura Vieira, Fábio Lourenço Romano, Erika Calvano Küchler, Christian Kirschneck, Daniela Silva Barroso de Oliveira, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto   +11 more
wiley   +1 more source

Migration of wear debris of polyethylene depends on bone microarchitecture

, 2009
The mechanism of hip arthroplasties loosening is related to the migration of wear debris throughout the implant environment. In vivo, polyethylene particles (PE) were shown to infiltrate the bone implant interface and the medullary spaces of the ...
Chappard, Daniel, Massin, Philippe, Daniel Chappard, M.F. Baslé, Hélène Libouban, Philippe Massin, P. Massin, Marchand-Libouban, Hélène, Baslé, Michel-Félix, Christine Gaudin, H. Marchand-Libouban, Philippe Mercier, Mercier, Philippe, D. Chappard, P. Mercier, Michel F. Baslé, Gaudin, Christine, C. Gaudin   +17 more
core   +1 more source

Estradiol replacement attenuates alendronate‐associated adverse effects on alveolar bone repair in ovariectomized rats

Journal of Periodontology, EarlyView.
Abstract Background Sodium alendronate (ALN) is widely used to treat postmenopausal osteoporosis, but both estrogen deficiency and antiresorptive therapy may impair alveolar bone repair after tooth extraction. A clinically relevant but insufficiently explored scenario involves estrogen‐deficient individuals receiving hormone replacement therapy (HRT ...
Pedro H. C. Isaias, Paulo G. B. Silva, Isabelly V. do Nascimento, Raul A. D. A. da Silva, Thayla M. do C. Sousa, Ana J. A. de de Vasconcelos, José V. M. Lemos, Fabrício B. Sousa, Ana P. N. N. Alves, Mário R. L. Mota   +9 more
wiley   +1 more source

Using Micro-CT Derived Bone Microarchitecture to Analyze Bone Stiffness - A Case Study on Osteoporosis Rat Bone

Frontiers in Endocrinology, 2015
Micro-computed tomography images can be used to quantitatively represent bone geometry through a range of computed attenuation-based parameters. Nonetheless, those parameters remain indirect indices of bone micro-architectural strength and require ...
Yuchin eWu, Samer eAdeeb, Michael Roman Doschak   +2 more
doaj   +1 more source

Immunological and periodontal benefits of prebiotic polydextrose in rats with induced periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Prebiotic therapy is a promising approach for managing periodontitis due to its potential benefits in modulating the microbiome and the immune response. This study aimed to evaluate the effects of the prebiotic (PREB) polydextrose (PDX) on the development of experimental periodontitis (EP) in rats.
Raquel de S. F Nassar, Marcella C. Ribeiro, Ana Carolina P. Hernandes, Laura Z. Gianduzzo, Vanessa de P. S. Pereira, Sérgio L. S. Salvador, Edilson Ervolino, Débora S. F. Sávio, Michel R. Messora, Flávia A. C. Furlaneto   +9 more
wiley   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Strontium ranelate improves bone microarchitecture in osteoporosis [PDF]

Rheumatology, 2009
In osteoporosis, disruption of bone remodelling leads to bone loss, microarchitectural damage and increased fracture risk, and the goal of any treatment for osteoporosis is to decrease this fracture risk. Available anti-resorptive and anabolic agents effectively achieve this goal by either suppressing or stimulating the activation frequency of bone ...
openaire   +2 more sources