Results 91 to 100 of about 21,763 (267)

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Rapid bone microarchitecture decline in older men with high bone turnover—the prospective STRAMBO study

International audienceOlder men with high bone turnover have faster bone loss. We assessed the link between the baseline levels of bone turnover markers (BTMs) and the prospectively assessed bone microarchitecture decline in men. In 825 men aged 60–87 yr,
Boyd, Steven, Chapurlat, Roland, Szulc, Pawel, Whittier, Danielle   +3 more
core   +1 more source

Determinants of bone damage: An ex-vivo study on porcine vertebrae. [PDF]

PLoS ONE, 2018
Bone's resistance to fracture depends on several factors, such as bone mass, microarchitecture, and tissue material properties. The clinical assessment of bone strength is generally performed by Dual-X Ray Photon Absorptiometry (DXA), measuring bone ...
Mohammad J Mirzaali, Flavia Libonati, Davide Ferrario, Luca Rinaudo, Carmelo Messina, Fabio M Ulivieri, Bruno M Cesana, Matteo Strano, Laura Vergani   +8 more
doaj   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

Early skeletal deteriorations following short-duration spaceflight

npj Microgravity
The adverse effects of spaceflight on skeletal health are well documented; however, the onset and underlying mechanism of these changes remain poorly understood.
Bryn E. Matheson, Matthias Walle, Annabel R. Bugbird, Marissa Rosenberg, Jaime Mateus, Steven K. Boyd   +5 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Variation in trabecular bone microarchitecture across rhesus macaque (Macaca mulatta) load-bearing joints. [PDF]

J Anat
Aging of bone density (BV/TV) is regional: Forelimb [left] elements gain bone sporadically (orange) but hind limb elements [right] lose bone globally (blue). Abstract Globally, human population structure is quickly trending older, increasing the prevalence and systemic burden of age‐related skeletal disorders such as osteoporosis.
Turcotte CM, Raghunath A, Ryan TM, DeMars LJD, Siracusa E, Patterson SK, Cayo Biobank Research Unit, Platt ML, Brent LJN, Snyder-Mackler N, Bauman SE, Montague MJ, Martinez MI, Williams SA, Antón SC, Higham JP, Kuo S.   +16 more
europepmc   +2 more sources

Deep Learning‐Assisted Design of Mechanical Metamaterials

Advanced Intelligent Discovery, EarlyView.
This review examines the role of data‐driven deep learning methodologies in advancing mechanical metamaterial design, focusing on the specific methodologies, applications, challenges, and outlooks of this field. Mechanical metamaterials (MMs), characterized by their extraordinary mechanical behaviors derived from architected microstructures, have ...
Zisheng Zong, Pu Wen, Zhiping Chai, Dunxuan Wu, Han Ding, Zhigang Wu   +5 more
wiley   +1 more source

AI‐BioMech: Deep Learning Prediction of Mechanical Behavior in Aperiodic Biological Cellular Materials

Advanced Intelligent Discovery, EarlyView.
AI‐BioMech is a deep learning framework that predicts the mechanical behavior of biological cellular materials directly from 2D images. By replacing traditional finite element analysis with semantic segmentation, it identifies stress and strain distributions with 99% accuracy, offering a high‐speed, scalable alternative for analyzing complex, aperiodic
Haleema Sadia, Marcelo A. Dias, Parvez Alam   +2 more
wiley   +1 more source

Trabecular Bone Structure Correlates with Hand Posture and Use in Hominoids [PDF]

, 2013
Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor and manipulative behaviours across extant hominoids may be reflected in differences in trabecular bone structure.
Smaers, JB, Tsegai, Zewdi J., Smaers, Jeroen B, Gross Thomas, Gross, T., Tsegai Zewdi J., Skinner Matthew M., Thomas Gross, Dieter H Pahr, Tsegai, Z. ; https://orcid.org/, Nguyen, N. Huynh, Skinner, M, Zewdi J. Tsegai (484661), Gross, T, Kivell, Tracy L., Zewdi J Tsegai, Pahr, D., Skinner, Matthew M, Skinner, M. ; https://orcid.org/, Matthew M Skinner, Pahr Dieter H., Kivell, T. ; https://orcid.org/, Kivell, TL, Nguyen, H., Smaers Jeroen B., Skinner, Matthew M., Tracy L. Kivell (484662), Kivell Tracy L., Nguyen N. Huynh, Nguyen, N Huynh, Gross, Thomas, Matthew M. Skinner (484667), Nguyen, NH, Jeroen B Smaers, Pahr, Dieter H, Tracy L Kivell, Thomas Gross (484663), N. Huynh Nguyen (484664), Dieter H. Pahr (484665), Pahr, Dieter H., Jeroen B. Smaers (484666), Tsegai, ZJ, Smaers, J., Pahr, DH, N Huynh Nguyen, Smaers, Jeroen B.   +45 more
core   +1 more source