Results 161 to 170 of about 4,065,576 (293)

The effect of BPA on bone mineral density (BMD) in rats

Osteoporosis and Sarcopenia, 2018
Hyuntak Kang, Hongje Kang, Daejin Nam
openaire   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Testosterone Replacement Therapy in Adolescents and Young Adults With Prader‐Willi Syndrome: Efficacy and Effects on Behaviour

Clinical Endocrinology, EarlyView.
ABSTRACT Context Hypogonadism in Prader‐Willi syndrome (PWS) is associated with decreased bone mineral density (BMD) in male adolescents and adults. Testosterone Replacement Therapy (TRT) improves BMD and sexual maturation, but TRT could aggravate pre‐existing challenging behaviour in male patients with PWS.
Wiebe R. Flamman, Demi J. Trueba‐Timmermans, Lionne N. Grootjen, Laura C. G. de Graaff, Joyce M. Geelen, Janielle A. E. M. van der Velden, Edmond H. H. M. Rings, Anita C. S. Hokken‐Koelega, Gerthe F. Kerkhof   +8 more
wiley   +1 more source

Tetrahedral Framework Nucleic Acid Delivery of miR‐210‐3p Promotes Femoral Bone Regeneration Through EFNA3/AKT/STAT3‐Mediated Immunomodulation

Cell Proliferation, EarlyView.
Schematic of tFNA‐miR‐210‐3p fabrication, macrophage regulation and femoral defect therapy: it enters macrophages, inhibits EFNA3 to induce M2 polarisation and boosts rat bone repair in vivo. ABSTRACT Persistent inflammation, insufficient vascularization and impaired osteogenesis limit the repair of critical‐sized femoral defects. Although microRNA‐210‐
Lei Hu, Kaixiao Xue, Jiahu Fang, Weitong Cui   +3 more
wiley   +1 more source

Musculoskeletal health among adults with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To describe the burden of, and investigate prognostic factors for, osteoarthritis, osteopenia and/or osteoporosis, spondylosis, and fracture, and to investigate the effectiveness of protocols for monitoring musculoskeletal disorders and interventions for managing osteoarthritis in adults with cerebral palsy (CP).
Jennifer M. Ryan, Jessica Burke, Rachel Byrne, Emily Capellari, Christina M Marciniak, Maram Sofiany, Reuel Jalal, Mark Peterson, The Adult CP Clinical Practice Guideline Working Group, Jan Willem Gorter, Ashley Harris Whaley, Christine Imms   +11 more
wiley   +1 more source

Genetically Proxied GIP‐GIPR Pathway Perturbation and Fracture Risk

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To determine whether genetic proxies for incretin pathway perturbation are associated with fracture risk and bone mineral density, providing human genetic evidence relevant to the skeletal safety of incretin‐based therapies. Materials and Methods We conducted drug‐target Mendelian randomisation using cis genetic variants near GIP, GIPR ...
Wenjie Cheng, Weijie Liu, Jie Wei, Chao Zeng, Houchen Lyu, Sizheng Steven Zhao   +5 more
wiley   +1 more source

A postmenopausal osteoporotic woman losing bone mineral density despite bisphosphonates [PDF]

, 2013
Bisphosphonates are pyrophosphate analogues, with a strong affinity for bones. They inhibit bone resorption and are currently the first choice of treatment for osteoporosis.
Nagammai T, Lai PSM, Vethakkan SR
core  

Weight Regain After Incretin Treatment: The Lean Mass Deficit Hypothesis and a Role for Testosterone Combination Therapy in Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann, Zsolt Bosnyak, Richard Jones, Monica Caliber   +3 more
wiley   +1 more source

Bone Mineral Density in Men - Original Investigation

, 2007
Aims: This study is designed to evaluate bone mineral density (BMD) in men who attend to Physical Medicine and Rehabilitation outpatient clinic. Patients and Medhods: 42 men were included into the study.
Duygu Geler Külcü, Burcu Yanık
core  

Sclerostin regulates bone morphogenetic protein (BMP) bioavailability through interactions with BMP complexes and fibrillin microfibrils

The FEBS Journal, EarlyView.
Sclerostin (SOST) is a multifunctional extracellular modulator of BMP and Wnt signaling. SOST binds with high affinity to fibrillin‐1 and fibrillin‐2, localizing it to fibrillin microfibrils and regulating its extracellular bioavailability. Fibrillin‐bound SOST cannot engage BMP‐7 prodomain (PD) complexes, revealing a competitive mechanism that ...
Annkatrin Correns, Fady Marcous, Steffen Lütke, Matthias Mörgelin, Philipp Barnowski, Ariane G. Furlan, Nathalie H. Schröder, Bodo Levkau, Sarah Riek, Martin Mollenhauer, Manuel Koch, Gerhard Sengle   +11 more
wiley   +1 more source