Results 181 to 190 of about 53,845 (250)

Spectrum of Hypogonadism and Its Management in Adolescents With Prader‐Willi Syndrome: A Retrospective Cohort Study Over 35 Years

open access: yesClinical Endocrinology, Volume 105, Issue 1, Page 51-59, July 2026.
ABSTRACT Context Adult data indicate that hypogonadism is underdiagnosed and undertreated in Prader‐Willi Syndrome (PWS). Objectives We aimed to describe the spectrum of pubertal development, and the diagnosis and treatment of hypogonadism in paediatric/adolescent patients with PWS. Design/Patients A retrospective cohort study of patients with PWS aged
Helen Nguyen   +2 more
wiley   +1 more source

Associations of Semaglutide With Skeletal Outcomes in People With Obesity, With and Without Type 2 Diabetes: A Target Trial Emulation

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5834-5847, July 2026.
ABSTRACT Aims To evaluate the associations between semaglutide initiation and long‐term skeletal outcomes in people with obesity, stratified by type 2 diabetes (T2D) status, using target trial emulation. Materials and Methods This retrospective cohort study used the TriNetX federated electronic health record network.
Yu‐Nan Huang   +8 more
wiley   +1 more source

Serum Leptin Exacerbates Osteoarthritis by Promoting Subchondral Bone H‐Type Vessel Angiogenesis via Activation of the PI3K/AKT Pathway

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease closely associated with obesity. Adipokines secreted by adipose tissue play critical roles in disease progression. This study focuses on the adipokine leptin and investigates its relationship with knee osteoarthritis.
Ruifu Li   +5 more
wiley   +1 more source

Oxypaeoniflorin Ameliorates Titanium Particle‐Stimulated Osteolysis by Targeting Nrf2 to Reprogram Mitochondrial Homeostasis in Osteoclasts

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Wear debris surrounding implants plays a crucial role in the development of periprosthetic osteolysis (PPO) by inducing the aggregation of osteoclasts around the prosthesis. Oxypaeoniflorin (OPF), a derivative of Paeoniflorin, is primarily sourced from the root of the traditional Chinese medicine peony and possesses anti‐inflammatory and ...
Feng Zhu   +10 more
wiley   +1 more source

Comparison of Lower Limb Muscle Strength Imbalances and Gait Performance in Postmenopausal Women with Healthy and Low Bone Mineral Density. [PDF]

open access: yesInt J Womens Health
Svobodová L   +8 more
europepmc   +1 more source

Combine Short‐Segment Fixation and Leverage Reduction Technique to Correct Kyphotic Angle in Kümmell's Disease

open access: yesOrthopaedic Surgery, Volume 18, Issue 7, Page 1518-1528, July 2026.
This study introduces a leverage reduction technique with short‐segment fixation for Kümmell's disease and kyphosis deformity. This advanced approach reliably restores vertebral height, corrects kyphosis, and improves clinical outcomes. ABSTRACT Objective Kümmell disease is a prevalent spinal condition characterized by vertebral fractures and ...
Yunwei Long   +4 more
wiley   +1 more source

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