Results 171 to 180 of about 53,845 (250)

Transient Hyperparathyroidism and Severe Intrauterine Osteopenia Linked to Novel Homozygous TRPV6 Deletion

Clinical Endocrinology, Volume 105, Issue 2, Page 197-204, August 2026.
ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore, Quinty Leusink, Femke Latta, Bram van der Eerden, Paul de Laat, Danielle van der Kaay, Joost Hoenderop   +6 more
wiley   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1535-1553, July 2026.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

A Fully Automated Pipeline for Vertebral Structural Assessment From Medical Images. Application Under Metastatic Conditions

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 7, July 2026.
We present an automated CT‐to‐simulation workflow to estimate structural response and fracture risk in metastasis‐affected vertebrae. Deep learning performs vertebral identification and segmentation, while CPD assigns geometry‐aware boundary conditions.
B. Gandia‐Vañó, J. M. Navarro‐Jiménez, J. J. Ródenas, E. Arana, E. Nadal   +4 more
wiley   +1 more source

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 139-149, July 2026.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu, Shiow‐Ing Wang, Shun‐Fa Yang   +2 more
wiley   +1 more source

D‐Allulose as a Low‐Calorie Sweetener: A 30‐Day Randomized, Double‐Blind Study on Gastrointestinal Tolerance and Systemic Safety to Support Its Application in Healthy Diets

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This graphical abstract presents the key design and findings of a 30‐day trial evaluating the safety of fermented D‐allulose in healthy Chinese adults. Fifty eligible adults were randomized to receive either low‐dose (24 g/day, n = 24) or high‐dose (36 g/day, n = 26) D‐allulose for 30 days.
Lijuan Qi, Junyu Ning, Jiangli Han, Nan Zhang, Wenjing Zhang, Fangfang Wang, Dan Li, Zinan Li, Yanmin Nie, Haiming Jing, Shan Gao   +10 more
wiley   +1 more source

Engineering Bone‐Targeted LNP Delivery of Anti‐Sclerostin Antibody mRNA for the Treatment of Osteoporosis

Journal of Biomedical Materials Research Part A, Volume 114, Issue 7, July 2026.
ABSTRACT Messenger RNA (mRNA) therapy represents a transformative platform in regenerative medicine, but its application to skeletal disorders remains limited by the pronounced hepatic tropism of conventional lipid nanoparticle (LNP) delivery systems.
Pengcheng Ren, Diaodiao Wang, Wenqiang Sun, Danning Li, Sidong Yang, Shudong Zhang, Yiquan Zhang, Yubo Liu, Peng Hu, Jiaxin Li, Qi Yao   +10 more
wiley   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, Volume 46, Issue 4, Page 966-988, July 2026.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Podocyte mPGES‐2 Determines Renal Aging and Contributes to Senile Osteoporosis

Aging Cell, Volume 25, Issue 7, July 2026.
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Dandan Zhong, Chang Hao, Mengyue Li, Jing Liu, Zheng Xu, Jianteng Zhou, Lu Zhao, Siyu Ni, Zhenchao Hu, Yue Sun, Yingying Zou, Dong Sun, Hao Guo, Zhanjun Jia, Dong Guo, Jun‐Li Cao, Ying Sun   +16 more
wiley   +1 more source

The genetic association between osteoprotegerin (OPG) gene polymorphisms and bone mineral density (BMD) in postmenopausal women: A meta-analysis: Erratum. [PDF]

Medicine (Baltimore), 2019
europepmc   +1 more source

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data

Aging Cell, Volume 25, Issue 7, July 2026.
This study investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis using data from the UK Biobank. Our findings indicated that the two conditions may act as reciprocal risk factors, with multiple potential biomarkers mediating the muscle‐bone relationship and suggested possible shared signals between the ...
Siqi Xu, Simin Wen, Xizeng Zong, Jianwei Zhu, Qiuling Du, Yu Li, Kunyan Wang, Peihua Cao, Changhai Ding, Yan Zhang, Guangfeng Ruan   +10 more
wiley   +1 more source