Results 181 to 190 of about 213,459 (247)

Bone Morphogenetic Protein-2 Plasmid DNA as a Substitute for Bone Morphogenetic Protein-2 Protein in Bone Tissue Engineering

Tissue Engineering Part A, 2013
Bone regeneration is one of the focus points in the field of regenerative medicine. A well-known stimulus of bone formation is bone morphogenetic protein-2 (BMP-2), which has already been extensively used in clinical applications. However, due to a short half-life, supraphysiological doses are applied resulting in severe side effects such as ectopic ...
Wegman, Fiona, van der Helm, Yvonne, Öner, F Cumhur, Dhert, Wouter J A, Alblas, Jacqueline   +4 more
openaire   +2 more sources

Bone Morphogenetic Protein‐2 Antagonizes Bone Morphogenetic Protein‐4 Induced Cardiomyocyte Hypertrophy and Apoptosis

Journal of Cellular Physiology, 2014
Our previous work showed that the expression of bone morphogenetic protein‐4 (BMP4) was up‐regulated in pathological cardiac hypertrophy models and BMP4 induced cardiomyocyte hypertrophy and apoptosis. Bone morphogenetic protein‐2 (BMP2) and BMP4 share greater than 80% amino acid homology and there exists an interaction between BMP2 and BMP4, so the ...
Jing, Lu, Bo, Sun, Rong, Huo, Yu-Chun, Wang, Di, Yang, Yue, Xing, Xiao-Lin, Xiao, Xin, Xie, De-Li, Dong   +8 more
openaire   +2 more sources

Polymeric electrospun scaffolds for bone morphogenetic protein 2 delivery in bone tissue engineering.

Journal of Colloid and Interface Science, 2018
HYPOTHESIS The development of novel scaffolds based on biocompatible polymers is of great interest in the field of bone repair for fabrication of biodegradable scaffolds that mimic the extracellular matrix and have osteoconductive and osteoinductive ...
J. Aragón, Simona Salerno, L. De Bartolo, S. Irusta, G. Mendoza   +4 more
semanticscholar   +1 more source

Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2

Clinical Orthopaedics and Related Research, 2002
Long-term clinical data have shown that reconstruction using bone allografts provide adequate function after extensive tumor surgery. Complications such as nonunion of allograft-host interface, infection, and allograft fracture often require major revision surgeries.
Francis Young-In, Lee, Stephen, Storer, Eric J, Hazan, Mark C, Gebhardt, Henry J, Mankin   +4 more
openaire   +2 more sources

Bone Morphogenetic Protein 2 Coordinates Early Tooth Mineralization

Journal of Dental Research, 2018
Formation of highly organized dental hard tissues is a complex process involving sequential and ordered deposition of an extracellular scaffold, followed by its mineralization. Odontoblast and ameloblast differentiation involves reciprocal and sequential epithelial-mesenchymal interactions.
Z. Malik, M. Alexiou, B. Hallgrimsson, A.N. Economides, H.U. Luder, D. Graf   +5 more
openaire   +2 more sources

Bone Morphogenetic Protein 2 Therapy for Craniofacial Surgery

Journal of Craniofacial Surgery, 2008
Between 2 and 10 years of age, the developing craniofacial skeleton poses a significant reconstructive challenge. Local autogenous bone is largely unavailable, distant bone grafts are fraught with significant morbidity and limited yield, and alloplastic materials are incompatible with the growing calvarium and facial skeleton.
Darren M, Smith, Gregory M, Cooper, Mark P, Mooney, Kacey G, Marra, Joseph E, Losee   +4 more
openaire   +2 more sources

RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2

The Journal of Bone and Joint Surgery-American Volume, 2003
It has been several decades since Marshall Urist's discovery of osteoinductive activity within demineralized bone protein extracts. Initially described in Science in 1965 1, Dr. Urist's remarkable discovery, an unexpected byproduct of intended research on the competitive binding of radionucleotides during bone mineralization, suggested that ...
Harvinder S, Sandhu, Safdar N, Khan
openaire   +2 more sources

Potential of Recombinant Human Bone Morphogenetic Protein-2 in Bone Regeneration

Implant Dentistry, 1999
Recombinant human bone morphogenetic protein (rhBMP-2) has been used as a bone substitute. This article describes the rhBMP-2 structure, mechanisms of action, carriers, advantages, safety, and recent clinical studies relevant to dentistry.
E, Barboza, A, Caúla, F, Machado
openaire   +2 more sources

Healing Bone Using Recombinant Human Bone Morphogenetic Protein 2 and Copolymer

Clinical Orthopaedics and Related Research, 1998
Middiaphyseal 2.5-cm segmental defects in the right femurs of 12 sheep were stabilized with stainless steel plates and implanted with (1) 2 mg recombinant human bone morphogenetic protein 2 and poly[D,L-(lactide-co-glycolide)] bioerodible polymer with autologous blood (n = 7), (2) 4 mg recombinant human bone morphogenetic protein 2 and poly[D,L ...
C A, Kirker-Head, T N, Gerhart, R, Armstrong, S H, Schelling, L A, Carmel   +4 more
openaire   +2 more sources

Bone morphogenetic protein‐2 for peri‐implant bone regeneration and osseointegration

Clinical Oral Implants Research, 1997
Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) induced bone regeneration and osseointegration was evaluated in supra‐alveolar peri‐implant defects in 5 beagle dogs. Alveolar bone was reduced 5 mm in height in mandibular premolar areas and the premolars were extracted.
T J, Sigurdsson, E, Fu, D N, Tatakis, M D, Rohrer, U M, Wikesjö   +4 more
openaire   +2 more sources