Results 41 to 50 of about 21,445 (301)

A finite element strategy applied to intramedullary nailing of the proximal femur [PDF]

, 2005
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.An intramedullary nail is a trauma treatment device used for fracture fixation of long bones. These devices are subject to failure, including lag screw
Simpson, David John
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

In vivo caprine model for osteomyelitis and evaluation of biofilm-resistant intramedullary nails [PDF]

, 2013
Bone infection remains a formidable challenge to the medical field. The goal of the current study is to evaluate antibacterial coatings in vitro and to develop a large animal model to assess coated bone implants.
Tran, PA, Engiles, JB, Born, CT, Hayda, Roman A., Thomas, NP, Young, Matthew D., Jarrell, JD, Tran, Nhiem, Tran, Phong A., Thomas, Nathan P., Tran, N, Hayda, RA, Born, Christopher T., Young, MD, Jarrell, John D., Engiles, Julie B.   +15 more
core   +1 more source

Do Surgeons Agree on Severity and Origin of Complications in Bone-lengthening Nails? An Inter- and Intra-rater Reliability Study [PDF]

, 2022
Background: Bone-lengthening nails result in various complications with different severity and origin. However, no universal reporting systemfor complications has been agreed upon, making it difficult to compare different nail designs and patient ...
Mikuzis, Mindaugas, Rahbek, Ole, Fridberg, Marie; id_orcid, Frost, Markus Winther; id_orcid, Kold, Søren Vedding; id_orcid   +4 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Intramedullary nailing of adult femoral fractures

Acta Orthopaedica et Traumatologica Turcica, 2021
Objectives: We evaluated the results of treatment of adult femoral fractures treated by intramedullary nails.\nMethods: Sixty-two patients (15 females, 48 males; mean age 29 years; range 16 to 62 years) with 64 femoral fractures were treated by ...
Oguz Durakbasa, Ugur Haklar, Hakan Tuygun, Metin Turkmen   +3 more
doaj  

Extra Articular Supracondylar Femur Fractures Managed with Locked Distal Femoral Plate or Supracondylar Nailing: A Comparative Outcome Study [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Despite recent evolution in the operating techniques and surgical implants, debate continues around the choice of implant for management of distal femur fractures.
SPS Gill, Ankit Mittal, Manish Raj, Pulkesh Singh, Jasveer Singh, Santosh Kumar   +5 more
doaj   +1 more source

Use of a Magnetic Bone Nail for Lengthening of the Femur and Tibia [PDF]

Journal of Orthopaedic Surgery, 2016
Purpose To report our experience with the PRECICE nail for limb lengthening in 23 patients. Methods Records of 15 female and 8 male patients aged 14 to 38 (mean, 23.6) years who underwent lengthening of the tibia (n=6) or femur (n=21 ...
Karakoyun, Özgür, Sokucu, Sami, Erol, Mehmet Fatih, Küçükkaya, Metin, Kabukcuoglu, Yavuz Selim   +4 more
openaire   +4 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source