Results 41 to 50 of about 1,012,906 (291)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Acta Orthopaedica et Traumatologica Turcica, 2021 Objectives: To evaluate long-term results of surgical treatment of fractures of the lateral humeral condyle in children.\nMethods: We evaluated 62 children (mean age 6.9 years) who underwent open reduction and osteosynthesis with Kirschner wires for ...
Metin Kucukkaya +3 more
doaj
Precision of the PRECICE® Internal Bone Lengthening Nail [PDF]
Clinical Orthopaedics and Related Research®, 2014 Previous designs of internal bone lengthening devices have been fraught with imprecise distraction, resulting in nerve injuries, joint contractures, nonunions, and other complications. Recently, a magnet-operated PRECICE nail (Ellipse Technologies, Inc, Irvine, CA, USA) was approved by the FDA; however, its clinical efficacy is unknown.We evaluated ...
Yatin M, Kirane +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Treatment of femoral shaft fractures by interlocking intramedullary nailing in adults
Acta Orthopaedica et Traumatologica Turcica, 2021 Objectives: We evaluated the radiological, clinical, and functional results of femoral shaft fractures treated by interlocking intramedullary nailing.\nMethods: Interlocking intramedullary nailing was performed in 48 femoral shaft fractures of 46 ...
M. Omer Arpacioglu +4 more
doaj
Comparison of carbon fibre and titanium intramedullary nails in orthopaedic oncology
Bone & Joint Open, 2022 Aims Due to their radiolucency and favourable mechanical properties, carbon fibre nails may be a preferable alternative to titanium nails for oncology patients.
Caleb M. Yeung +6 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Revista Brasileira de OrtopediaOBJECTIVE: To perform a retrospective radiographic assessment of the reduction and implant position in the femoral head in patients with pertrochanteric fractures treated with cephalomedullary nailing in the lateral position versus traction table ...
Eric Fernando de Souza +4 more
doaj +1 more source
RECURRENT ROTATIONAL DEFORMITY OF THE FEMUR AFTER STATIC LOCKING OF INTRAMEDULLARY NAILS
, 1997 Rotational deformity following intramedullary nailing may cause symptoms and require surgical correction by osteotomy. Reamed, locked intramedullary nailing may be performed, but concern about cortical blood supply and potential pulmonary dysfunction ...
T. Miclau +5 more
core +1 more source