Results 51 to 60 of about 1,012,906 (291)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

CEPHALOMEDULLARYS FRACTURE FIXATION IN THE MANAGEMENT OF UNSTABLE HIP FRACTURES.

Revista Ciencias Biomédicas, 2015
Introduction: unstable hip fractures in elderly people are a public health problem. The treatment is carried out with osteolysis and cephalomedullarys bone nails of which there are others designs.
Fonseca-Caro John Fredy, Matson-Carballo Gustavo, Pereira-Betancourt Carlos, Rivera-Martínez Edgardo   +3 more
doaj  

Biodegradable pure Mg fixation nails for guided bone regeneration membrane: In vitro and in vivo evaluation

Journal of Magnesium and Alloys
Guided Bone Regeneration (GBR) relies on membrane nails to stabilize barrier membranes and promote osseous healing. However, conventional titanium nails need secondary removal surgeries and may impair osteogenesis.
Bo Zhang, Guanqi Liu, Jianhua Zhu, Di Peng, Guanxi Wu, Siyu Liu, Jianmin Han, Chuanbin Guo   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Case Report of Congenital Bilateral Absence of Nail, Middle and Distal Phalanges of the Toes

پزشکی بالینی ابن سینا, 2007
Introduction: Anonychia is a rare condition in which the nails of the fingers and/or the toes are not formed. Case Report: 18 years old man is reported with lack of nails and in addition, bone in the middle and distal phalanges of both feet since birth.
Ali Reza Saied, Alia Ayatollahi Mousavi
doaj  

Flexible intramedullary nails for limb lengthening: a comprehensive comparative study of three nails types

, 2019
This study aims to investigate the comparative study of calcium phosphate coatings for flexible intramedullary nails (FINs) used to lengthen long tubular bones.
Golovkin, AS, Popkov, A, Ignatov, VP, Gorback, EN, Khlusov, IA, Stankevich, KS, Bolbasov, EN, Popkov, DA, Anissimov, YG, Tverdokhlebov, S, Kononovich, NA, Bouznik, VM   +11 more
core   +1 more source

Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy

Arthritis Care &Research, EarlyView.
Objective We aimed to determine whether the short‐term response to biologics in biologic‐naive psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods Patients with PsA who started on biologic therapy from the year 2000 to 2025 were included for analysis.
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source

Influence of initial biomechanical environment provided by fibrous composite intramedullary nails on bone fracture healing

, 2017
Long bone fractures are primarily treated with internal fixation devices, and intramedullary (IM) nails are the most commonly used. Reamed and unreamed surgical procedures are commonly used to attach IM nails to fractured bones.
Faris Tarlochan, Kim, Jinha, Mehboob, Ali, Chang, Seung-Hwan, Hassan Mehboob, Seung-Hwan Chang, Jinha Kim, Ali Mehboob, Mehboob, Hassan, Tarlochan, Faris   +9 more
core   +1 more source