Results 71 to 80 of about 1,012,906 (291)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Static Study and Finite Element Analysis of a New Method of Fixation of a Medial Humerus Fracture by an Intramedullary Nailing System Analyzed by the ANSYS Workbench 16.2 Calculus Code

Nano Biomedicine and Engineering, 2019
Comminuted fractures of the humerus are generally treated with the intramedullary rod fixed by screws or locking plate system, and clinical results are satisfactory. We also know very well that the success of this agriculture depends on the stability and
Brahim Keddar, Benaoumer Aour, Samir Zahaf, Chetti Boualem, Fouzia Bouchakour, Zahra Najafi Vafa   +5 more
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Effect of axial stress-loaded magnesium alloy intramedullary nails on bone fracture healing

Mg alloy intramedullary nails dynamically share load and release ions to accelerate anisotropic bone remodeling.
Shijie Zhu, Shaokang Guan, Chaoyang Jin, Mingran Zheng, Jingyu Zhao, Junfei Huang, Wenxiang Li, Delin Ma, Qichao Zhao, Jun Wang, Xiaochao Wu, Liguo Wang, Yunhao Zhang   +12 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

A Novel Dynamic Compression Angle-Stable Interlocking Intramedullary Nail: Description, Validation, and Model Evaluation

Veterinary Medicine International
The stabilization of long-bone fractures using intramedullary nails offers significant biological advantages for bone healing. Nevertheless, the mechanical stability of the implant–bone interface remains suboptimal due to the absence of models capable of
Luís Gustavo Gosuen Gonçalves Dias, Thiago André Salvitti Sá Rocha, Caio Afonso Santos Malta, Bruno Watanabe Minto, Alefe Luiz Caliani Carrera   +4 more
doaj   +1 more source

Predictive value of tip apex distance and calcar-referenced tip apex distance for cut-out risk in intertrochanteric femur fractures treated with double lag screw proximal femoral nails

Acta Orthopaedica et Traumatologica Turcica
Objective: Cut-out is a major mechanical complication following proximal femoral nailing for intertrochanteric femur fractures. Tip apex distance (TAD) and calcar-referenced TAD (CalTAD) are key radiographic parameters used to predict this complication.
Mehmet Akan, Dıhye Sezen, Hayati Kart
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source