Results 91 to 100 of about 21,445 (301)
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
, 2021 Background: Two-stage revision for periprosthetic knee infection is challenging in cases of massive bone loss and instability. The present study aims to describe our experience with an alternative technique of reinforced cement spacer, usually necessary ...
Vasco C. +6 more
core +1 more source
Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Materials & DesignBone fractures in the lower limbs, pose significant challenges in orthopaedic treatment due to the need for effective stabilization and healing. To contextualize recent advances, data indicate that lower limb fractures account for 20.2 % of all fractures.
Ali Mehboob +2 more
doaj +1 more source
Acta Orthopaedica et Traumatologica Turcica, 2021 Objectives: We assessed the long-term functional results of surgical treatment of distal intra-articular humeral fractures, together with the factors having influence on the outcome.\nMethods: Thirty-four patients (25 males, 9 females; mean age 38 years;
Mustafa Urguden +2 more
doaj
, 2004 Intramedullary nails are tube-like implantable medical devices that are commonly used to treat long bone fractures. Interlocking screws, that pass from one side of the bone to the other, through holes at either end of the nail, provide additional ...
Shepherd, Duncan E.T.; id_orcid +1 more
core +1 more source
Development of a test system to analyze different hip fracture osteosyntheses under simulated walking [PDF]
, 2012 The mechanical complications of osteosyntheses after hip fractures are previously investigated by mostly static or dynamic uniaxial loading test systems.
Lenich, Andreas +5 more
core +1 more source
Advanced Science, EarlyView.In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu +18 more
wiley +1 more source
Biomechanical design considerations of a 3D-printed tibiotalocalcaneal nail for ankle joint fusion
3D Printing in MedicineTibiotalocalcaneal (TTC) arthrodesis treatment using intramedullary nails faces significant challenges due to inadequate bone integration and mechanical stability.
Kin Weng Wong +5 more
doaj +1 more source