Results 71 to 80 of about 1,467,095 (255)

A hybrid protocol CLAG-M, a possible player for the first-line therapy of patients with mixed phenotype acute leukemia. A Polish Adult Leukemia Group experience

Frontiers in Oncology
IntroductionMixed-phenotype acute leukemia (MPAL) is a rare disease with poor prognosis. So far, no standard approach has been established as the “know-how” of MPAL is based only on retrospective analyses performed on small groups of patients.Materials ...
Magdalena Karasek, Anna Armatys, Marek Skarupski, Marek Skarupski, Łukasz Bołkun, Katarzyna Budziszewska, Joanna Drozd-Sokołowska, Ewa Zarzycka, Patrycja Mensah-Glanowska, Małgorzata Gajewska, Janusz Hałka, Janusz Hałka, Agnieszka Kopacz, Witold Prejzer, Olga Chyrko, Tomasz Wróbel, Agnieszka Wierzbowska, Agnieszka Wierzbowska, Marta Sobas   +18 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Genetic effect of basal metabolic rate on the benign neoplasm of bone and articular cartilage: a Mendelian randomization study

Frontiers in Oncology
BackgroundPrevious studies have found an association between basal metabolic rate (BMR) and various malignant neoplasms, including bone tumors. BMR is also associated with bone mineral density, but the causality between BMR and benign neoplasms of bone ...
Guijin Huang, Guijin Huang, Guijin Huang, Ying Yao, Ying Yao, Ying Yao, Lin Fan, Lin Fan, Lin Fan, Sisi Li, Sisi Li, Sisi Li   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

P435: ANALYSIS OF MYELOBLAST IMMUNOPHENOTYPE PROFILE IN ACUTE MYELOID LEUKAEMIA AS PREDICTOR FOR CLINICAL OUTCOME

HemaSphere, 2022
M. Sobas, M. Nowak, D. Szymczak, I. Andrasiak, T. Wróbel   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Efficacy of ruxolitinib in myeloid neoplasms with PCM1-JAK2 fusion gene

, 2015
The response of myeloproliferative neoplasms with PCM1-JAK2 fusion genes can be long-lived, without use of allogeneic bone marrow ...
Pietra, D, Lierman, Els, Cavalloni, Chiara, Lierman, E, Pietra, Daniela, Milanesi, Chiara, RUMI, ELISA, CAZZOLA, MARIO, Kralovics, R, Astori, Cesare, Casetti, Ilaria, Selleslag, Dominik, Selleslag, D, Vandenberghe, Peter, 4, ., Dambruoso, I, Bellini, M, Milosevic, Jelena D., Vandenberghe, P, Milosevic, Jd, Astori, C, Bellini, Marta, Dambruoso, Irene, Casetti, I, Milanesi, C, Kralovics, Robert, Cavalloni, C   +26 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Giant chondrosarcoma of the sternal body: case report [PDF]

Revista Brasileira de Cirurgia Plástica
Chest wall tumors are relatively uncommon, representing 1 to 2% of all neoplasms, and approximately 5% of thoracic neoplasms. Sarcomas are rare tumors with heterogeneous presentation.
José Dalvo Maia, Antero Gomes, Ryan Nogueira Lima, Maria de Fátima de Brito Coutinho Nogueira Lima   +3 more
doaj   +1 more source

Myelodysplastic Neoplasms/Syndromes (MDS)

Myelodysplastic neoplasms/syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by peripheral cytopenias and dysplastic features in blood and bone ...
Gurnari C., Robin M.
core   +1 more source