Results 171 to 180 of about 1,336,774 (305)

Metabolic checkpoints in bone remodeling: from dysregulation to targeted therapies. [PDF]

Clinics (Sao Paulo)
Zhao X, Han X, Wang B, Gao W, Zhang Z.
europepmc   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Heme Oxygenase-1 in Bone Remodeling: Molecular Mechanisms and Therapeutic Implications. [PDF]

Biomolecules
Pattananandecha T, Apichai S, Saenjum C, Surh YJ.   +3 more
europepmc   +1 more source

Numerical investigation of signal mechanotransduction of bone cells - application to bone remodeling

Numerical investigation of signal mechanotransduction of bone cells - application to bone remodeling. The understanding of signal mechanotransduction of bone cells is directly related to mechanical activation of bone remodeling processes, i.e ...

core  

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

The Role of SIRT1 in Mediating Bone Marrow Edema and Its Interface With Bone Remodeling. [PDF]

Immun Inflamm Dis
Chen Y, Li X, Zheng Z, Liu Z, Xu T, Tang Y.   +5 more
europepmc   +1 more source

Bone remodeling and type 2 diabetes: Effects of acute exercise

, 2010
Bone remodeling and type 2 diabetes: Effects of acute ...
I Levinger (12276464), Steve Selig (13095918), G Jerums (13612804), R Zebaze (13696417), D Hare (13300374), E Seeman (13280226)   +5 more
core  

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Bone-seeking nanomaterials for rebalancing bone remodeling in osteoporosis. [PDF]

Int J Pharm X
Wang F, Liang F, Zhou X, Ding Y, Wu M, Li N, Wang F, Yan W.   +7 more
europepmc   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source