Results 251 to 260 of about 356,262 (352)

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Targeted disruption of PRC1.1 complex enhances bone remodeling. [PDF]

Nat Commun
Xing L, Xu J, Gong M, Liu Y, Li X, Meng L, Du R, Zhou Y, Ouyang Z, Liu X, Tao S, Cao Y, Liu C, Gao F, Han R, Shen H, Dong Y, Xu Y, Li T, Chen H, Zhao Y, Fan B, Sui L, Feng S, Liu J, Liu D, Wu X.   +26 more
europepmc   +1 more source

Effects of Fit and Bonding Characteristics of Femoral Stems on Adaptive Bone Remodeling

, 1994
Harrie Weinans, R. Huiskes, H.J. Grootenboer   +2 more
openalex   +2 more sources

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Manganese Deficiency and Mn₂O₃ Nanoparticles Supplementation Disrupt Bone Remodeling and Mineral Matrix Maturation in Rats. [PDF]

Int J Mol Sci
Cholewińska E, Juśkiewicz J, Fotschki B, Ognik K.   +3 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Comparative Fractal Analysis on Orthopantomography Images of Bone Remodeling Changes at 3 Months Between Natural Socket Healing and Immediate Implant Placement. [PDF]

Diagnostics (Basel)
Radu A, Ionescu M, Khaddour AS, Munteanu CM, Iacov Crăițoiu MM, Cojocaru MO, Sălan AI, Marinescu IR, Mercuț R, Popescu SM.   +9 more
europepmc   +1 more source

Monosodium urate crystal depletion and bone erosion remodeling during pegloticase treatment in patients with uncontrolled gout: Exploratory dual-energy computed tomography findings from MIRROR RCT

Nicola Dalbeth, John K. Botson, Kenneth G. Saag, Ada Kumar, Lissa Padnick‐Silver, Brian LaMoreaux, Fabio Becce   +6 more
openalex   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Retraction: Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source