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Encyclopedia of Molecular Pharmacology, 2021
Quilhac, Alexandra +1 more
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Quilhac, Alexandra +1 more
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British Dental Journal, 1992
Bone is a specialised connective tissue that, together with cartilage, makes up the skeleton. These tissues serve three functions: (a) mechanical support and site of muscle attachment for locomotion; (b) protection for vital organs and bone marrow and (c) a metabolic reserve of ions for the entire organism, especially calcium and phosphate.
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Bone is a specialised connective tissue that, together with cartilage, makes up the skeleton. These tissues serve three functions: (a) mechanical support and site of muscle attachment for locomotion; (b) protection for vital organs and bone marrow and (c) a metabolic reserve of ions for the entire organism, especially calcium and phosphate.
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Bone remodelling in osteoarthritis
Nature Reviews Rheumatology, 2012The classical view of the pathogenesis of osteoarthritis (OA) is that subchondral sclerosis is associated with, and perhaps causes, age-related joint degeneration. Recent observations have demonstrated that OA is associated with early loss of bone owing to increased bone remodelling, followed by slow turnover leading to densification of the subchondral
David B, Burr, Maxime A, Gallant
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Proteases and bone remodelling
Cytokine & Growth Factor Reviews, 2009Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. These interactions can be established either through a cell-cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains.
S, Georges +5 more
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Therapie, 2004
The physiological maintenance of bone mass is ensured by bone tissue renewal, allowing old bone tissue to be replaced by an equivalent mass of bone matrix. After mechanical or hormonal stress activation, a phase of resorption by osteoclasts occurs, followed by a phase of bone formation by osteoblasts. Among the multiple factors involved in osteoblastic
Martine, Cohen-Solal +1 more
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The physiological maintenance of bone mass is ensured by bone tissue renewal, allowing old bone tissue to be replaced by an equivalent mass of bone matrix. After mechanical or hormonal stress activation, a phase of resorption by osteoclasts occurs, followed by a phase of bone formation by osteoblasts. Among the multiple factors involved in osteoblastic
Martine, Cohen-Solal +1 more
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2014
Skeletal buildup and maintenance is ensured by modeling and remodeling processes. Bone modeling works mainly during organism growth and is characterized by bone formation prevailing on resorption: The two processes are carried out simultaneously but not at the same location.
Brunetti G. +2 more
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Skeletal buildup and maintenance is ensured by modeling and remodeling processes. Bone modeling works mainly during organism growth and is characterized by bone formation prevailing on resorption: The two processes are carried out simultaneously but not at the same location.
Brunetti G. +2 more
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Mechanically adaptive bone remodelling
Journal of Biomechanics, 1982Removal of the ulna in mature sheep causes a slight increase in peak principal walking strains in the radius which can be recorded by rosette strain gauges. The overstrain on the cranial surface of the radius (20%) was more than twice that on the caudal surface (8%) yet over the 50 weeks following ulnar osteotomy new bone was deposited predominantly on
L E, Lanyon +3 more
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Hematopoiesis and bone remodeling
Blood, 2011Erythropoietin (Epo) is a polypeptide hormone produced in kidney. It stimulates the proliferation of erythroid progenitor cells in response to hypoxia. In this issue of Blood , the report of Singbrant et al clearly shows the indirect effect of Epo on bone remodeling and its importance for the Epo-
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