Results 141 to 150 of about 1,847,810 (404)
Journal of Pharmacological Sciences, 2008 The vertebrate skeleton is richly innervated with adrenergic and peptidergic nerve terminals, and these play important roles in bone remodeling. Recent studies have generally shown that increased sympathetic nervous activity causes bone loss via an ...
Akifumi Togari, Michitsugu Arai
doaj
The Role of Transforming Growth Factor Beta-1 in Bone Remodeling [PDF]
, 2009 Bone remodeling depends on the precise coordination of bone resorption by the osteoclasts and bone formation by the osteoblasts. It is proposed that osteoclastic bone resorption releases factors to initiate bone formation, thereby, coupling the bone ...
Tang, Yi
core +1 more source
Role of cytokines in bone resorption [PDF]
Journal of Cellular Biochemistry, 1993 AbstractOsteoclastic bone resorption is modulated in humans by powerful osteotropic factors which are generated in the immediate vicinity of bone resorbing surfaces. These factors are released from marrow mononuclear cells and from some bone cells, and some are actually incorporated into the noncollagenous bone matrix from where they are released when ...
openaire +3 more sources
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
BioMed Research International, 2015 Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process ...
R. Florêncio-Silva +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao +7 more
wiley +1 more source
Bone resorption: an actor of dental and periodontal development?
Frontiers in Physiology, 2015 Dental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated.
Andrea eGama +9 more
doaj +1 more source
Thrombin, a stimulator of bone resorption
Bioscience Reports, 1983 It is shown that thrombin (0.1–7 units/ml) stimulates calcium mobilization and bone matrix degradation, as indicated by release of [3H]proline, from cultured calvarial bones. The second finding in this paper, that indomethacin blocks the stimulating effect of thrombin on bone resorption, is consistent with the concept that prostaglandin synthesis may ...
G. T. Gustafson, Ulf H. Lerner
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TGF-β1-induced Migration of Bone Mesenchymal Stem Cells Couples Bone Resorption and Formation
Nature Network Boston, 2009 Bone remodeling depends on the precise coordination of bone resorption and subsequent bone formation. Disturbances of this process are associated with skeletal diseases, such as Camurati-Engelmann disease (CED).
Yi Tang +13 more
semanticscholar +1 more source
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species
Advanced Science, EarlyView.This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu +15 more
wiley +1 more source
Advanced Science, EarlyView.A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou +9 more
wiley +1 more source