Results 121 to 130 of about 251,654 (302)

Multiple verification in computational modeling of bone pathologies

, 2011
We introduce a model checking approach to diagnose the emerging of bone pathologies. The implementation of a new model of bone remodeling in PRISM has led to an interesting characterization of osteoporosis as a defective bone remodeling dynamics with ...
A. Aziz, D.T. Gillespie, E. Bartocci, E. Bartocci, E. Bartocci, Emanuela Merelli, Erik de Vink, G. Karsenty, Ion Petre, L.J. Raggatt, M. Calder, M. Kwiatkowska, M. Kwiatkowska, N. Paoletti, Nicola Paoletti, P. Lió, Pietro Liò, R. Barbuti, R. Hanada, S. Jabbar, S.C. Manolagas, T.E. Pronk   +21 more
core   +2 more sources

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Accuracy of vertical bitewing and bisect periapical radiography techniques in anterior mandibular teeth interdental bone resorption

مجله دانشکده دندانپزشکی اصفهان, 2009
Introduction: Alveolar bone level is changed due to the balance between bone formation and resorption. Radiographic examination has an important role in the diagnosis and treatment of periodontal diseases. This study was performed to compare the accuracy
Mohamad Shah Abouei, Ehsan Hekmatian E, Mahdi Adibrad, Ayoob Bahador Ghobadi   +3 more
doaj  

RELATIONSHIP BONE MINERAL DENSITY AND RESORPTION OF ALVEOLAR [PDF]

Osteoporosis is a degenerative disease characterized by reduced metabolic bone mass and bone micro-architect so that the risk of failure. Low bone mineral density is a clinical condition in patients with osteoporosis.Abstract:\ud \ud Objectives ...
Rieuwpassa, Irene Edith
core  

Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds. [PDF]

, 2019
The instructive capabilities of extracellular matrix-inspired materials for osteoprogenitor differentiation have sparked interest in understanding modulation of other cell types within the bone regenerative microenvironment.
Bischoff, David, Dewey, Marley J, Foulad, David, Harley, Brendan AC, He, Tong-Chuan, Lee, Justine C, Miller, Timothy A, Reid, Russell R, Ren, Xiaoyan, Tiffany, Aleczandria S, Yamaguchi, Dean T, Zhou, Qi   +11 more
core  

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. [PDF]

, 2010
IntroductionThe interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects
Adamopoulos, Iannis E, Blumenschein, Wendy, Bowman, Edward P, Chao, Cheng-Chi, Geissler, Richard, Iwakura, Yoichiro, Laface, Drake, McClanahan, Terrill   +7 more
core   +1 more source

Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes for Vascularized Bone Regeneration

Advanced Science, EarlyView.
Schematic illustration of injectable PDA‐modified GelMA microspheres loaded with BioPre‐Exos for vascularized bone regeneration. ABSTRACT Critical‐sized bone defects remain a highly challenging clinical problem due to insufficient intrinsic self‐healing capacity.
Lijun Li, Hao Zhang, Lingtong Sun, Yingfeng Su, Yang Xu, Jian Huang, Jingchao Wen, Jinjin Zhu, Jianjun Ma, Wenbin Xu   +9 more
wiley   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source