Results 101 to 110 of about 1,145,483 (297)

Novel Molecules that Regulate Bone Formation and Bone Resorption [PDF]

, 2011
Osteoporosis is a disease characterized by decreased bone mass and microarchitectural deterioration of bone. Bone loss occurs when the increased bone resorption that occurs with age is not compensated by a corresponding increase in bone formation ...
Linares, Gabriel Robert
core   +1 more source

Perawatan Ortodonti pada Kasus Mutilasi dengan Resorpsi Tulang Alveolar dan Resesi Gingiva (Laporan Kasus)

Journal of Dentistry Indonesia, 2015
In the mutilated case in adults, generally malocclusion is often accompanied by less support of periodontal tissues, such as alveolar bone resorption and gingival recession. The treatment of orthodontic is to arrange the teeth into good position and good
Retno Widayati, Widokinasih Idris
doaj   +1 more source

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

, 2020
The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type.
Wei-Ren Shen, Adya Pramusita, Itaru Mizoguchi, Fumitoshi Ohori, Aseel Marahleh, Yasuhiko Nara, Hideki Kitaura, Takahiro Noguchi, Jiawei Qi, Ria Kinjo   +9 more
core   +1 more source

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model [PDF]

, 2012
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU).
Buenzli, P. R., Smith, D. W., Junhwan Jeon, David W. Smith, Cummings, P. T., Jeon, J., Peter Pivonka, Cummings, Peter T.; id_orcid, Pivonka, P., Pascal R. Buenzli, Pivonka, Peter, Peter T. Cummings, Smith, David W., Jeon, Junhwan, Buenzli, Pascal R.   +14 more
core   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Bone resorption: an actor of dental and periodontal development?

Frontiers in Physiology, 2015
Dental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated.
Andrea eGama, Andrea eGama, Benjamin eNavet, Benjamin eNavet, Jorge William Vargas, Jorge William Vargas, Beatriz eCastaneda, Beatriz eCastaneda, Frederic eLezot, Frederic eLezot   +9 more
doaj   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Influence of alveolar bone thickness and bucco-palatal inclination on root resorption of lateral incisors in unilateral maxillary impacted canines: a retrospective observational study

BMC Oral Health
Background This study aimed to investigate the potential associations between alveolar bone thickness, bucco-palatal inclination of maxillary lateral incisors, and lateral incisor root resorption in patients with unilateral maxillary impacted canines ...
Weiman Sun, Yuanyuan Yang, Chenghuan Liu, Houxuan Li, Lang Lei   +4 more
doaj   +1 more source

Osteoprotegerin deficiency attenuates strontium-mediated inhibition of osteoclastogenesis and bone resorption

, 2011
Strontium (Sr) exerts an anabolic and antiresorptive effect on bone, but the mechanism remains unknown. Osteoprotegerin (OPG) expressed by osteoblasts plays an important role in regulating bone homeostasis by inhibiting osteoclastogenesis and bone ...
Zhaoyang Li, Zhou, G, Keith DK Luk, Lu, WW, X Sherry Liu, X Edward Guo, Liu, XS, Guo, XE, Li, Z, Songlin Peng, Guangqian Zhou, Peng, S, Luk, KDK, W William Lu   +13 more
core   +1 more source