Results 101 to 110 of about 175,216 (263)

Developmental differences in cortical bone structure in chimpanzee and human femora reflect early locomotor independence in humans

open access: yesThe Anatomical Record, EarlyView.
Abstract The cortical bone structure of long bone diaphyses changes throughout growth via skeletal modeling and has important implications for bone strength and structural integrity. Ontogenetic trends in diaphyseal structure have been identified in both chimpanzees and humans but it is not yet clear how these trends compare given notable differences ...
Karen R. Swan   +3 more
wiley   +1 more source

Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men

open access: yes, 2013
Objectives: Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people.
Heer, M.   +4 more
core  

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

open access: yesAnimal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen   +5 more
wiley   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK Pathways

open access: yesArthritis &Rheumatology, EarlyView.
Objective Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla   +13 more
wiley   +1 more source

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

open access: yesArthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid   +34 more
wiley   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo   +9 more
wiley   +1 more source

Fresh Talus Allograft Preparation for the Treatment of a Large Off‐Track Hill‐Sachs Lesion

open access: yesArthroscopy Techniques, EarlyView.
Abstract Large off‐track Hill‐Sachs lesions present a significant challenge in the management of recurrent anterior shoulder instability, particularly in young, active patients. Traditional Hill‐Sachs management procedures include remplissage, coracoid transfer and free bone block reconstruction, which all carry associated limitations, including non ...
Michael J. Nocek   +5 more
wiley   +1 more source

Autologous Cancellous Bone Interposition to Enhance Tendon‐Bone Integration in Hamstring Tendon Anterior Cruciate Ligament Reconstruction: A Surgical Technique

open access: yesArthroscopy Techniques, EarlyView.
Abstract Hamstring tendon autografts remain a popular choice for anterior cruciate ligament reconstruction due to their favorable biomechanical properties and reduced donor‐site morbidity; however, delayed tendon‐to–bone integration and tunnel widening continue to limit outcomes when compared with bone–patellar tendon–bone grafts.
Cillian J. Keogh   +2 more
wiley   +1 more source

Arthroscopic Allogeneic Bone Strip Grafting for Recurrent Shoulder Dislocation With Critical Glenoid Bone Loss: A Free Graft Suspension Fixation Technique

open access: yesArthroscopy Techniques, EarlyView.
Abstract In patients with recurrent anterior shoulder dislocation and glenoid bone loss between 10% and 20%, isolated Bankart repair remains associated with a certain rate of postoperative redislocation. The optimal management for this patient subset is controversial. We describe an all‐arthroscopic technique using allogeneic bone strips for free graft
Yingbin Wu   +5 more
wiley   +1 more source

TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts

open access: yes, 1998
Choi, Y   +9 more
core   +1 more source

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