Results 111 to 120 of about 1,145,483 (297)
Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation
Advanced Science, EarlyView.Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan +10 more
wiley +1 more source
Advanced Science, EarlyView.Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao +7 more
wiley +1 more source
The influence of the surface energy and roughness of implants on bone resorption
, 1989 We investigated the possibility that the macrophages which are seen around implants may stimulate bone resorption and cause loosening. We found that macrophages release mediators that stimulate bone resorption, and that the amount of resorption ...
N Rushton, T Rae, DW Murray
core +1 more source
A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery
Advanced Science, EarlyView.A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu +16 more
wiley +1 more source
HeliyonObjective: Understanding the characteristics of alveolar bone resorption in an East Asian population after maxillary incisor extraction and providing a reference for implant treatment plans.
Fang Qu +7 more
doaj +1 more source
Advanced Science, EarlyView.Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou +11 more
wiley +1 more source
A bone-resorption surface-targeting nanoparticle to deliver anti-miR214 for osteoporosis therapy
, 2017 Mingxiang Cai,1,* Li Yang,2,* Shufan Zhang,1 Jiafan Liu,2 Yao Sun,1 Xiaogang Wang2 1Engineering Research Center of Tooth Restoration and Regeneration, Department of Oral Implantology, School of Stomatology, Tongji University, Shanghai, 2Department of ...
Liu J +5 more
core
PERIPROSTHETIC BONE RESORPTION
, 1996 Using a rat model, we created a bone-to-titanium interface and applied phagocytosable high-density polyethylene pArticles between the bone and implant, either initially or when the interface had matured.
P. Herbertsson, P. Aspenberg
core +1 more source
Advanced Science, EarlyView.MSNs serve as a robust vehicle for CRISPRa‐mediated Reln induction, driving bone repair through the establishment of a neurogenic‐supportive microenvironment. ABSTRACT Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, while the mechanisms and new strategies underlying neurogenic bone regeneration ...
Shuai Lin +9 more
wiley +1 more source
Alveolar bone resorption after tooth extraction [PDF]
, 2012 Alveolar ridge resorption has long been considered an unavoidable consequence of tooth extraction. Atrophy of the alveolar bone may cause significant esthetic and surgical problems in implantation, as well as at prosthetic and restorative dentistry ...
Popovski, Stipica, Dimova, Cena
core +1 more source