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Bone resorption and bone metastasis risk

Medical Hypotheses, 2018
Breast cancer tumors have a tendency to metastasize to the bone. After development of a bone metastasis, the median survival time is 40 months. Currently, little is known about the modifiable risk factors for developing bone metastases in women diagnosed with breast cancer. One possible modifiable risk factor is increased bone resorption.
Katlynn M, Mathis   +5 more
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Bone deposition, bone resorption, and osteosarcoma

Journal of Orthopaedic Research, 2010
AbstractBone deposition and bone resorption are ongoing dynamic processes, constituting bone remodeling. Some bone tumors, such as osteosarcoma (OS), stimulate focal bone deposition. OS is the most common primary bone tumor in children and young adults.
Sílvia Regina Caminada, Toledo   +7 more
openaire   +2 more sources

PERIPROSTHETIC BONE RESORPTION

The Journal of Bone and Joint Surgery. British volume, 1996
Using a rat model, we created a bone-to-titanium interface and applied phagocytosable high-density polyethylene pArticles between the bone and implant, either initially or when the interface had matured. No fibrous membrane developed and no bone resorption was found.
P, Aspenberg, P, Herbertsson
openaire   +2 more sources

Bone resorption and prosthodontics

The Journal of Prosthetic Dentistry, 1973
Abstract The phenomenon of bone resorption and its importance to dentistry, specifically prosthodontics, have been briefly reviewed. At a skeletal level, bone resorption is thought to be controlled by the opposing actions of parathyroid hormone and thyrocalcitonin. The importance of vitamin D and phosphate in this mechanism was discussed.
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Subperiosteal Bone Resorption

New England Journal of Medicine, 2014
A 45-year-old man was admitted to the hospital with anorexia, fatigue, and thirst. About 10 years earlier, he had been treated for urinary calculi. Evaluation showed an elevated serum calcium level and a serum intact PTH level of 3844 pg per milliliter (normal range, 10.3 to 65.9).
Takafumi Taguchi, Yoshio Terada
openaire   +1 more source

Bone Resorption by Osteoclasts

Science, 2000
Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in skeletal turnover so that bone resorption exceeds bone formation. Bone resorption is the unique function of the osteoclast, and anti-osteoporosis therapy to date has targeted this cell.
openaire   +2 more sources

Molecular Chaperones Stimulate Bone Resorption

Calcified Tissue International, 1999
Molecular chaperones, also known as heat shock proteins (hsp), are intracellular proteins found in all cells that catalyze protein folding. We have discovered that one class of bacterial molecular chaperone, the chaperonins, are potent inducers of bone resorption.
S P, Nair   +5 more
openaire   +2 more sources

Cortical Bone Resorption in Osteoporosis

Calcified Tissue International, 1997
A study was made of 110 women: 35 healthy premenopausal, 40 healthy postmenopausal, and 35 women diagnosed as having postmenopausal osteoporosis. The postmenopausal women had similar ages and years since menopause (YSM). In all of the women, total bone mass was evaluated by dual-energy X-ray absorptiometry and metacarpal morphometry was evaluated by ...
F, Aguado   +3 more
openaire   +2 more sources

Immunoreactive collagenase and bone resorption

Biochimica et Biophysica Acta (BBA) - General Subjects, 1981
1. Active mouse bone collagenase is excluded from its inhibitory antibody by preincubation of that antibody with various forms of inactive enzyme, e.g. 'procollagenase', some collagenase-inhibitor complexes or partially denatured or degraded collagenase. This property allows the detection of several enzymatically inactive forms of collagenase. 2.
C, Francois-Gillet   +3 more
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Mechanisms involved in bone resorption

Biogerontology, 2002
Osteoclasts, which are present only in bone, are multinucleated giant cells with the capacity to resorb mineralized tissues. These osteoclasts are derived from hemopoietic progenitors of the monocyte-macrophage lineage. Osteoblasts or bone marrow-derived stromal cells are involved in osteoclastogenesis through a mechanism involving cell-to-cell contact
openaire   +2 more sources

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